Biological roles of fatty acid composition of phospholipids.

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In this study, we examined the mechanism of fatty acid remodeling and its biological roles. We focused two phospholipases called iPLA1a and iPLA1g. We knockdowned the two iPLA1s by RNAi technique in HeLa cells and examined the fatty acid composition of the cells. We found that fatty acid remodening of phospholipid at the sn-1 position was dramatically delayed in iPLA1a-knockdowned HeLa cells. In addition, abnormal mitochondria were frequently observed in the iPLA1a-knockdowned cells. These results indicate that fatty acid remodeling at the sn-1 position of phospholipids by iPLA1a has a critical role in the function of mitochondria.