Development of an adjuvant therapy for severe malaria with the hemoglobin vesicle, an artificial oxygen carrier.

开发利用血红蛋白囊泡（一种人造氧载体）治疗严重疟疾的辅助疗法。

• 批准号: 24659193
• 负责人: KANO Shigeyuki
• 金额: $ 2.5万
• 依托单位: 独立行政法人国立国際医療研究センター
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659193/
• 关键词: 原虫; マラリア; ヘモグロビン小胞体; 補助療法; 感染症; 微生物; 輸血; 人工赤血球

We investigated the potential of HbV as an adjuvant therapy for severe malaria using rodent malaria models. Balb/c mice were inoculated with Plasmodium berghei. The HbV or saline infection was started in tail vein from 6-day after inoculation. No significant difference in parasitemia and body weight of the mice was observed between the HbV and saline treated groups after daily treatment until they died. However, we observed that, immediately after its administration, the HbV treated mice became more active comparing the saline treated mice. To evaluate the effects of the HbV treatment, the rotarod performance test was carried out. The riding time on the rotarod compared between the 2 groups revealed significant extension of the time in mice treated with the HbV. The HbV transfusion may have improved the anemia and mitigated the complication of severe malaria in mice. The HbV has high potential as adjuvant therapy for human as well to save the lives of patients in the endemic areas.

我们使用啮齿动物疟疾模型研究了HbV作为重度疟疾辅助治疗的潜力。Balb/c小鼠接种伯氏疟原虫。从接种后第6天开始尾静脉感染HbV或生理盐水。在每天治疗后直至死亡，在HbV和盐水治疗组之间未观察到小鼠的寄生虫血症和体重的显著差异。然而，我们观察到，在其施用后，与盐水处理的小鼠相比，HbV处理的小鼠立即变得更活跃。为了评估HbV治疗的效果，进行了转棒性能测试。两组之间比较的在旋转棒上的骑行时间显示用HbV处理的小鼠的时间显著延长。乙型肝炎病毒输注可能改善了小鼠的贫血并减轻了严重疟疾的并发症。乙型肝炎病毒有很大的潜力作为人类的辅助治疗，以及挽救病人的生命，在流行地区。

项目成果

Development of an adjuvant therapy for severe malaria with the hemoglobin vesicle, an artificial oxygen carrier.

开发利用血红蛋白囊泡（一种人造氧载体）治疗严重疟疾的辅助疗法。

• 发表时间: 2014
• 作者: Tamura;T;Akbari;M.;Kimura K.;Kimura;D.;Yui;K.;矢野和彦
• 通讯作者: 矢野和彦

Development of an adjuvant therapy for severe malaria with the hemoglobin vesicle,an artificial oxygen carrier

人工氧载体血红蛋白囊泡辅助治疗重症疟疾的开发

• 发表时间: 2014
• 作者: Inoue T;Hagiyama M;Enoki E;Sakurai MA;Tan A;Wakayama T;Iseki S;Murakami Y;Fukuda K;Hamanishi C;Ito A.;Yano Kazuhiko,Iwagami Moritoshi,Sakai Hiromi,Kano Shigeyuki
• 通讯作者: Yano Kazuhiko,Iwagami Moritoshi,Sakai Hiromi,Kano Shigeyuki

重症マラリアの合併症とその治療

重症疟疾的并发症及其治疗

• 发表时间: 2013
• 作者: Tamura;T;Akbari;M.;Kimura K.;Kimura;D.;Yui;K.;矢野和彦;狩野繁之
• 通讯作者: 狩野繁之

人工酸素運搬体による重症マラリア合併症の補助療法の開発

使用人工氧载体开发严重疟疾并发症的辅助治疗

• 发表时间: 2014
• 作者: 矢野和彦;岩上盛敏;酒井宏水;狩野繁之
• 通讯作者: 狩野繁之