Acridine orange photodynamic antimicrobial chemotherapy for drug resistant bacterias

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The effect of acridine orange photodynamic antimicrobial chemotherapy for drug resistant bacterias was examined.Growth was significantly suppressed at 50 microgram/ml of acridine orange solution in Acinetobacter, vancomycin-resistant enterococci, enterococci, methicillin-resistant Staphylococcus aureus, Staphylococcus aureus, the growth rate was 4%, 17%, 18%, 7%, and 15% respectively.It was not revealed mechanism of growth inhibition of bacteria by the present method. Since the relatively strong growth inhibitory effect was observed against methicillin-resistant Staphylococcus aureus ,I was considered that acridine orange photodynamic antimicrobial chemotherapy was also possible clinical application in infection of bone and soft tissue.