Development of novel physicochemical and molecular biological therapy for the metastatic bone tumors

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We developed the novel physicochemical and molecular biological therapy for the metastatic bone tumors. First, we showed that NF-kappaB decoy suppress the cell invasion and cell growth of breast cancer cell line at the bone metastatic site, by inhibiting the expression of VCM-1and ICAM-1. Second, we demonstrated the effect of hyperthermic treatment strategy with magnetic nano-particle. Third, Photodynamic therapy(PDT) using acridine orange is proved to be effective treatment not only for the sarcoma, but also for metastatic bone tumors. Actually we started clinical application of PDT for the bone metastases. Finally, we developed the radiofrequency ablation (RFA) combined with thermo-sensitive liposome-embedding doxorubicin in an effort to safe and effective RFA treatment for the metastatic spinal tumor. Further investigation is necessary.