Exploration of immunological risk factors for osteoporosis

骨质疏松症免疫学危险因素的探讨

• 批准号: 24659298
• 负责人: NAKAMURA Kazutoshi
• 金额: $ 2.58万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659298/
• 关键词: 免疫; 骨粗鬆症; 疫学研究; 骨密度; 抗体; 加齢; 骨代謝; 炎症; リスク要因

The aim of the study was to explore potential risk factors for osteoporosis and its related health conditions in epidemiologic studies. Immunological and inflammation markers in serum were measured, and their associations with bone mass and cognitive function were tested. Serum Cytomegalovirus antibody titers were significantly correlated with spinal bone mineral density in the Yokogoshi Study (r=-0.12), and Cytomegalovirus antibody titers were significantly correlated with 2-year changes in Mini-Mental State Examination scores in the Yamato Study (r=0.30). It is concluded that previous viral infection could predict osteoporosis and/or cognitive decline.

该研究的目的是在流行病学研究中探讨骨质疏松症及其相关健康状况的潜在危险因素。测量了血清中的免疫和炎症标志物，并测试了它们与骨量和认知功能的关联。在横越研究中，血清巨细胞病毒抗体滴度与脊柱骨矿物质密度显着相关（r=-0.12），在大和研究中，巨细胞病毒抗体滴度与简易精神状态检查评分的 2 年变化显着相关（r=0.30）。结论是，既往病毒感染可以预测骨质疏松症和/或认知能力下降。