Randomized controlled trial of calcium supplementation

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The aim of this study was to reveal a possible effect of calcium supplementation on bone loss of postmenopausal women. Four-hundred fifty women were divided into the following three groups : 1) receiving 500 mg/day of calcium supplement, 2) receiving 250 mg/day of calcium supplement, and 3) placebo. Loss of bone mineral density in femoral neck and lumbar spine for two years was compared among the three groups. Bone loss of lumbar spine in the two calcium supplement groups was significantly smaller than the placebo group. A calcium supplement 250 mg/day prevents spinal bone loss of Japanese women.