The confounding effect of cryptic relatedness for environmental risks of systolic blood pressure on cohort studies.

收缩压环境风险的神秘相关性对队列研究的混杂影响。

• 批准号: 24659316
• 负责人: SHIBATA Kyoko
• 金额: $ 0.58万
• 依托单位: Tohoku University (2013)Yamagata University (2012)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659316/
• 关键词: 血縁構造化; 疫学研究; 交絡因子; 血縁構造

We investigated the confounding effect of unadjusted cryptic relatedness (CR) among a rural cohort in the relationship between environmental risk factors (body mass index, smoking status, alcohol consumption) and systolic blood pressure (SBP). We applied the methods of population-based whole-genome association studies for the analysis of the genome-wide SNP data in 1622 subjects, and detected 20.2% CR in this cohort population. In conclusion, we found a confounding effect of CR in the relationship between SBP and environmental risk factors was not negligible. In our study, we showed that heritability for liability might reflect on the estimation of regression coeffients between SBP and environmental risk factors, because they vary with environmental risk factors that differ across some unsuspected relatedness.

我们调查了农村人群中未经调整的隐性相关性（CR）对环境风险因素（体重指数、吸烟状况、饮酒）和收缩压（SBP）之间关系的混杂效应。我们应用基于人群的全基因组关联研究方法对 1622 名受试者的全基因组 SNP 数据进行了分析，并在该队列人群中检测到 20.2% 的 CR。总之，我们发现 CR 在 SBP 和环境风险因素之间的关系中的混杂效应不可忽略。在我们的研究中，我们表明责任遗传力可能反映在 SBP 和环境风险因素之间回归系数的估计上，因为它们随着环境风险因素的变化而变化，而环境风险因素在一些意想不到的相关性方面有所不同。

项目成果

The confounding effect of cryptic relatedness for environmental risks of systolic blood pressure on cohort studies.

• DOI: 10.1002/mgg3.4
• 发表时间: 2013-05
• 期刊: MOLECULAR GENETICS & GENOMIC MEDICINE
• 影响因子: 2
• 作者: Shibata, Kyoko;Hozawa, Atsushi;Tamiya, Gen;Ueki, Masao;Nakamura, Tomohiro;Narimatsu, Hiroto;Kubota, Isao;Ueno, Yoshiyuki;Kato, Takeo;Yamashita, Hidetoshi;Fukao, Akira;Kayama, Takamasa
• 通讯作者: Kayama, Takamasa