Identification of novel transporter for exporting iron to establish effective therapy for chronic liver disorder

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As excess iron accumulation in body cause oxidative stress, it is needed that effective iron excretion system. Surprisingly, there is only one molecule named FPN1 has been identified in this system. In this study, we aimed to identify novel iron exporting protein by focusing on the genes that expressions are regulated by Nrf2 having central role for anti-oxidative stress gene induction. By using microarray analysis, some candidates such as SLC40A1, HFE, FECH, CYBRD1, ISCU, SLC25A37 and TFRC were listed up, however, all of those did not have iron exporting activity.