Identification of novel transporter for exporting iron to establish effective therapy for chronic liver disorder

鉴定用于输出铁的新型转运蛋白以建立慢性肝病的有效治疗方法

• 批准号: 24659358
• 负责人: MIZOKAMI Yuji
• 金额: $ 2.41万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659358/
• 关键词: 肝臓学; 鉄代謝; トランスポーター

As excess iron accumulation in body cause oxidative stress, it is needed that effective iron excretion system. Surprisingly, there is only one molecule named FPN1 has been identified in this system. In this study, we aimed to identify novel iron exporting protein by focusing on the genes that expressions are regulated by Nrf2 having central role for anti-oxidative stress gene induction. By using microarray analysis, some candidates such as SLC40A1, HFE, FECH, CYBRD1, ISCU, SLC25A37 and TFRC were listed up, however, all of those did not have iron exporting activity.

由于体内过量的铁积累会引起氧化应激，因此需要有效的铁排泄系统。令人惊讶的是，在该系统中仅鉴定出一种名为FPN1的分子。在这项研究中，我们的目的是确定新的铁输出蛋白，通过关注的基因表达调控的Nrf2具有核心作用的抗氧化应激基因诱导。通过基因芯片分析，筛选出了SLC40A1、HFE、FECH、CYBRD1、ISCU、SLC25A37和TFRC等6个候选铁转运蛋白，但均不具有铁转运活性。

项目成果

Obesity in p62-KO mice is prevented by estradiol

雌二醇可预防 p62-KO 小鼠的肥胖

• 发表时间: 2014
• 作者: Eiji Warabi;Kentaro Akiyama;Junichi Shoda;Tetsuro Ishii
• 通讯作者: Tetsuro Ishii

p62/Sqstm1欠損は中枢におけるレプチン抵抗性により過食を引き起こす

p62/Sqstm1 缺乏会因中枢瘦素抵抗而导致食欲亢进

• 发表时间: 2013
• 作者: 蕨栄治;石井哲郎;正田純一.
• 通讯作者: 正田純一.