使用肿瘤定向对比介质进行胰腺癌的新型超声成像-猫眼课题宝

使用肿瘤定向对比介质进行胰腺癌的新型超声成像

批准号：

24659372

负责人：

KATO Junji

金额：

$2.41万

依托单位：

Sapporo Medical University

依托单位国家：

日本

项目类别：

Grant-in-Aid for Challenging Exploratory Research

财政年份：

2012

资助国家：

日本

项目状态：

已结题

起止时间：

2012 至 2013

来源：

https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659372/

关键词：

超音波造影剤膵癌フコースナノキャリアペルフルブタンリポソーム

项目摘要

项目成果

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中文摘要

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英文摘要

Patients with pancreatic ductal carcinoma (PDAC) are dismal prognosis due to absence of effective modality to diagnose at early stage. We have recently developed a novel targeting nanoparticle for PDAC using fucose receptor mediated-endocytosis (PLoS ONE, 2012). Our nanoparticles carrying anti-cancer drugs could specifically delivered agents to PDAC cells and suppressed tumor growth. We then utilized this strategy for diagnosing PDAC as a novel ultrasound imaging. We encapsulated perfulbutane (PFB) into our nanoparticles and succeeded to image PDAC as a tumor in xenografted rat model using ultrasound sonography.

期刊论文(21)

专著(0)

科研奖励(0)

会议论文

A case of idiopathic encapsulating peritoneal sclerosis with intractable ileus successfully treated by surgery and steroid therapy

特发性包裹性腹膜硬化合并顽固性肠梗阻经手术和类固醇治疗成功治愈一例

DOI： --

发表时间： 2013

期刊：

Clin J Gastroenterol

影响因子： 1

作者：

[Ikeda Y, Takada K, Kato J, et al]

通讯作者： et al

Diagnostic validity of CT gastrography versus gastroscopy for primary lesions in gastric cancer: evaluating the response to chemotherapy, a retrospective analysis

DOI： 10.1007/s10120-012-0217-7

发表时间： 2013-10-01

期刊：

GASTRIC CANCER

影响因子： 7.4

作者：

[Takahashi, Sho, Hirayama, Michiaki, Kato, Junji]

通讯作者： Kato, Junji

A phase II study of neoadjuvant combination chemotherapy with docetaxel, cisplatin, and S-1 for locally advanced resectable gastric cancer: nucleotide excision repair (NER) as potential chemoresistance marker

DOI： 10.1007/s00280-013-2073-5

发表时间： 2013-03-01

期刊：

CANCER CHEMOTHERAPY AND PHARMACOLOGY

影响因子： 3

作者：

[Hirakawa, Masahiro, Sato, Yasushi, Kato, Junji]

通讯作者： Kato, Junji

Treatment of pancreatic fibrosis with siRNA against a collagen-specific chaperone in vitamin A-coupled liposomes

DOI： 10.1136/gutjnl-2011-301746

发表时间： 2013-09-01

期刊：

GUT

影响因子： 24.5

作者：

[Ishiwatari, Hirotoshi, Sato, Yasushi, Niitsu, Yoshiro]

通讯作者： Niitsu, Yoshiro

Fucosylated TGF-β receptors transduces a signal for epithelial-mesenchymal transition in colorectal cancer cells.

DOI： 10.1038/bjc.2013.699

发表时间： 2014-01-07

期刊：

BRITISH JOURNAL OF CANCER

影响因子： 8.8

作者：

[Hirakawa, M., Takimoto, R., Tamura, F., Yoshida, M., Ono, M., Murase, K., Sato, Y., Osuga, T., Sato, T., Iyama, S., Miyanishi, K., Takada, K., Hayashi, T., Kobune, M., Kato, J.]

通讯作者： Kato, J.