A novel ultrasound imaging for pancreatic cancer using tumor directed-contrast media

使用肿瘤定向对比介质进行胰腺癌的新型超声成像

• 批准号: 24659372
• 负责人: KATO Junji
• 金额: $ 2.41万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659372/
• 关键词: 超音波造影剤; 膵癌; フコース; ナノキャリア; ペルフルブタン; リポソーム

Patients with pancreatic ductal carcinoma (PDAC) are dismal prognosis due to absence of effective modality to diagnose at early stage. We have recently developed a novel targeting nanoparticle for PDAC using fucose receptor mediated-endocytosis (PLoS ONE, 2012). Our nanoparticles carrying anti-cancer drugs could specifically delivered agents to PDAC cells and suppressed tumor growth. We then utilized this strategy for diagnosing PDAC as a novel ultrasound imaging. We encapsulated perfulbutane (PFB) into our nanoparticles and succeeded to image PDAC as a tumor in xenografted rat model using ultrasound sonography.

胰腺导管癌（PDAC）由于缺乏有效的早期诊断手段，预后极差。我们最近开发了一种使用岩藻糖受体介导的内吞作用的新型PDAC靶向纳米颗粒（PLoS ONE，2012）。我们的携带抗癌药物的纳米颗粒可以特异性地将药物递送到PDAC细胞并抑制肿瘤生长。然后，我们利用这种策略诊断PDAC作为一种新的超声成像。我们将全氟丁烷（PFB）封装到我们的纳米颗粒中，并成功地使用超声超声成像将PDAC作为异种移植大鼠模型中的肿瘤。

项目成果

A case of idiopathic encapsulating peritoneal sclerosis with intractable ileus successfully treated by surgery and steroid therapy

特发性包裹性腹膜硬化合并顽固性肠梗阻经手术和类固醇治疗成功治愈一例

• 发表时间: 2013
• 期刊: Clin J Gastroenterol
• 影响因子: 1
• 作者: Ikeda Y;Takada K;Kato J;et al
• 通讯作者: et al

Diagnostic validity of CT gastrography versus gastroscopy for primary lesions in gastric cancer: evaluating the response to chemotherapy, a retrospective analysis

• DOI: 10.1007/s10120-012-0217-7
• 发表时间: 2013-10-01
• 期刊: GASTRIC CANCER
• 影响因子: 7.4
• 作者: Takahashi, Sho;Hirayama, Michiaki;Kato, Junji
• 通讯作者: Kato, Junji

A phase II study of neoadjuvant combination chemotherapy with docetaxel, cisplatin, and S-1 for locally advanced resectable gastric cancer: nucleotide excision repair (NER) as potential chemoresistance marker

• DOI: 10.1007/s00280-013-2073-5
• 发表时间: 2013-03-01
• 期刊: CANCER CHEMOTHERAPY AND PHARMACOLOGY
• 影响因子: 3
• 作者: Hirakawa, Masahiro;Sato, Yasushi;Kato, Junji
• 通讯作者: Kato, Junji

Treatment of pancreatic fibrosis with siRNA against a collagen-specific chaperone in vitamin A-coupled liposomes

• DOI: 10.1136/gutjnl-2011-301746
• 发表时间: 2013-09-01
• 期刊: GUT
• 影响因子: 24.5
• 作者: Ishiwatari, Hirotoshi;Sato, Yasushi;Niitsu, Yoshiro
• 通讯作者: Niitsu, Yoshiro

Fucosylated TGF-β receptors transduces a signal for epithelial-mesenchymal transition in colorectal cancer cells.

• DOI: 10.1038/bjc.2013.699
• 发表时间: 2014-01-07
• 期刊: BRITISH JOURNAL OF CANCER
• 影响因子: 8.8
• 作者: Hirakawa, M.;Takimoto, R.;Tamura, F.;Yoshida, M.;Ono, M.;Murase, K.;Sato, Y.;Osuga, T.;Sato, T.;Iyama, S.;Miyanishi, K.;Takada, K.;Hayashi, T.;Kobune, M.;Kato, J.
• 通讯作者: Kato, J.