Targeting anticancer drug delivery to pancreatic cancer cells using a fucose-bound nanoparticle approach

由于其侵袭性和缺乏有效的治疗方法，胰腺导管腺癌的预后很差。因此，迫切需要新的战略来改善治疗和生存。我们开发了X结合的纳米颗粒作为载体，用于将抗癌药物特异性地递送到癌细胞。含有Cy 5的X结合脂质体。5或顺铂被有效地递送到表达CA 19 -9的胰腺癌细胞中。体内注射的携带顺铂的X结合脂质体成功地递送至胰腺癌细胞，介导有效的肿瘤生长抑制以及延长小鼠异种移植模型中的存活。这种方式代表了胰腺癌细胞靶向治疗的新策略。

Owing to its aggressiveness and the lack of effective therapies, pancreatic ductal adenocarcinoma has a dismal prognosis. New strategies to improve treatment and survival are therefore urgently required. We developed X-bound nanoparticles as vehicles for delivery of anticancer drugs specifically to cancer cells. X-bound liposomes containing Cy5. 5 or Cisplatin were effectively delivered into CA19-9 expressing pancreatic cancer cells. Intravenously injected X-bound liposomes carrying Cisplatin were successfully delivered to pancreatic cancer cells, mediating efficient tumor growth inhibition as well as prolonging survival in mouse xenograft models. This modality represents a new strategy for pancreatic cancer cell-targeting therapy.