Targeting anticancer drug delivery to pancreatic cancer cells using a fucose-bound nanoparticle approach

使用岩藻糖结合纳米颗粒方法将抗癌药物递送至胰腺癌细胞

• 批准号: 21390231
• 负责人: KATO Junji
• 金额: $ 11.4万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390231/
• 关键词: 癌; 糖鎖; 内科; (1)癌; (2)糖鎖

Owing to its aggressiveness and the lack of effective therapies, pancreatic ductal adenocarcinoma has a dismal prognosis. New strategies to improve treatment and survival are therefore urgently required. We developed X-bound nanoparticles as vehicles for delivery of anticancer drugs specifically to cancer cells. X-bound liposomes containing Cy5. 5 or Cisplatin were effectively delivered into CA19-9 expressing pancreatic cancer cells. Intravenously injected X-bound liposomes carrying Cisplatin were successfully delivered to pancreatic cancer cells, mediating efficient tumor growth inhibition as well as prolonging survival in mouse xenograft models. This modality represents a new strategy for pancreatic cancer cell-targeting therapy.

由于其侵袭性和缺乏有效的治疗方法，胰腺导管腺癌的预后很差。因此，迫切需要新的战略来改善治疗和生存。我们开发了X结合的纳米颗粒作为载体，用于将抗癌药物特异性地递送到癌细胞。含有Cy 5的X结合脂质体。5或顺铂被有效地递送到表达CA 19 -9的胰腺癌细胞中。体内注射的携带顺铂的X结合脂质体成功地递送至胰腺癌细胞，介导有效的肿瘤生长抑制以及延长小鼠异种移植模型中的存活。这种方式代表了胰腺癌细胞靶向治疗的新策略。

项目成果

Drug resistance is dramatically restored by hedgehog inhibitors in CD34+ leukemic cells

• DOI: 10.1111/j.1349-7006.2009.01111.x
• 发表时间: 2009-05-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Kobune, Masayoshi;Takimoto, Rishu;Kato, Junji
• 通讯作者: Kato, Junji

A phase I trial of arterial infusion chemotherapy with gemcitabine and 5-fluorouracil for unresectable biliary tract cancer

吉西他滨和 5-氟尿嘧啶动脉灌注化疗治疗不可切除胆道癌的 I 期试验

• 发表时间: 2011
• 期刊: Int J Clin Oncol
• 影响因子: 3.3
• 作者: Hayashi T;Kobune M;Takimoto R;Kato J
• 通讯作者: Kato J

Novel missense mutation in the TMPRSS6 gene in a Japanese female with iron-refractory iron deficiency anemia

• DOI: 10.1007/s12185-011-0881-0
• 发表时间: 2011-07-01
• 期刊: INTERNATIONAL JOURNAL OF HEMATOLOGY
• 影响因子: 2.1
• 作者: Sato, Tsutomu;Iyama, Satoshi;Kato, Junji
• 通讯作者: Kato, Junji

膵癌に対する新規ミサイル療法の開発

开发一种新的胰腺癌导弹疗法

• 发表时间: 2010
• 作者: 瀧本理修;加藤淳二
• 通讯作者: 加藤淳二

Argon plasma coagulation treatment of hemorrhagic radiation proctopathy: the optimal settings for application and long-term outcome.

• DOI: 10.1016/j.gie.2010.11.015
• 发表时间: 2011-03
• 期刊: Gastrointestinal endoscopy
• 影响因子: 7.7
• 作者: Y. Sato;T. Takayama;T. Sagawa;M. Hirakawa;H. Ohnuma;K. Miyanishi;Tsutomu Sato;R. Takimoto;M. Kobune;K. Okamoto;H. Takeuchi;J. Kato