Roles of IL-33 and IL-33 receptors in immune responses

IL-33 和 IL-33 受体在免疫反应中的作用

• 批准号: 24659470
• 负责人: NAKAE Susumu
• 金额: $ 2.41万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659470/
• 关键词: アレルギー; 免疫

IL-33 induces Th2 cytokines by various types of cells through its receptors, ST2 and IL-1RAcP. In certain immune responses, the phenotypes are known to be inconsistent between IL-33-deficient and ST2-deficient mice, suggesting the existence of the other receptor(s) for IL-33 and/or the other ligand(s) for ST2. In the study, we attempted to identify the binding molecule(s) of IL-33.

IL-33通过其受体ST 2和IL-1 RAcP诱导各种类型细胞的Th 2细胞因子。在某些免疫应答中，已知IL-33缺陷型和ST 2缺陷型小鼠之间的表型不一致，表明存在IL-33的其他受体和/或ST 2的其他配体。在本研究中，我们试图鉴定IL-33的结合分子。