Evaluation of F-18 labeled fluoroacetate as an imaging probe for glial function

F-18 标记的氟乙酸盐作为神经胶质功能成像探针的评价

• 批准号: 24659560
• 负责人: KIYONO Yasushi
• 金额: $ 2.41万
• 依托单位: University of Fukui
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659560/
• 关键词: 放射線; 放射性医薬遺品; グリア; PET; 放射性医薬品

It is expected to develop imaging probes for glial function. Therefore, in this study, F-18 labeled acetic acid derivative, F-18 labeled fluoroacetate was evaluated as an imaging probe for glial function.In in vitro cell uptake experiments, it was observed that F-18 labeled fluoroacetate was uptaken into astocytes. On the other hand, F-18 labeled fluoroacetate was not uptaken into microglia. In PET imaging experiments, the accumulation of F-18 labeled fluoroacetate in the brain was peaked at 3 min post injection, and then the radioactivity was maintained in the same level.These results suggest that F-18 labeled fluoroacetae has the possibility to image the glial function and to measure the energetic metabolism in the glia.

预计将开发神经胶质功能的成像探针。因此，本研究将F-18标记的乙酸衍生物、F-18标记的氟乙酸盐作为胶质细胞功能的成像探针进行评价。在体外细胞摄取实验中，观察到F-18标记的氟乙酸盐被星形胶质细胞摄取。 另一方面，F-18 标记的氟乙酸盐没有被小胶质细胞吸收。在PET成像实验中，F-18标记的氟乙酸盐在大脑中的积累在注射后3分钟达到峰值，然后放射性保持在相同水平。这些结果表明F-18标记的氟乙酸盐有可能对神经胶质细胞功能进行成像并测量神经胶质细胞的能量代谢。

项目成果

Fully automated production of [^<18>F]fluoroacetate on a compact FDG synthesizer

在紧凑型FDG合成仪上全自动生产[^18F]氟乙酸盐

• 发表时间: 2014
• 作者: T.Mori;R.Arai;D.Blampain;T.Kosuga;T.Asai;Y.Fujibayashi;H.Okazawa;Y.Kiyono
• 通讯作者: Y.Kiyono

Fully automated production of [18F]fluoroacetate on a compact FDG synthesizer.

在紧凑型 FDG 合成器上全自动生产 [18F]氟乙酸盐。

• 发表时间: 2014
• 作者: T.Mori;R.Arai;D.Blampain;T.Kosuga;T.Asai;Y.Fujibayashi;H.Okazawa;Y.Kiyono
• 通讯作者: Y.Kiyono

汎用型PET薬剤自動合成システムの開発と実用性試験.

通用PET药物自动合成系统的开发及实用性测试。

• 发表时间: 2013
• 作者: 森 哲也;高木 健志;藤林 靖久;岡沢 秀彦;清野 泰
• 通讯作者: 清野 泰

Fully automated production of [18F]fluoroacetate on IBA Synthera platform

在 IBA Synthera 平台上全自动生产 [18F]氟乙酸盐

• 发表时间: 2013
• 作者: Mori T;Arai R;Blampain D;Gameiro-Paris C;Kosuga T;Asai T;Fujibayashi Y;Okazawa H;Kiyono Y.
• 通讯作者: Kiyono Y.

Development of a flexible synthesis module system for F-18 labeled PET tracer

开发用于 F-18 标记 PET 示踪剂的灵活合成模块系统

• 发表时间: 2014
• 作者: T.Mori;T.Takaki;Y.Fujibayashi;T.Asai;H.Okazawa;Y.Kiyono
• 通讯作者: Y.Kiyono