Development of a new therapeutid agent for internal radiation therapy and monitoring using Auger electron emitting radionuclides

使用俄歇电子发射放射性核素开发用于内部放射治疗和监测的新型治疗剂

• 批准号: 19689026
• 负责人: KIYONO Yasushi
• 金额: $ 17.31万
• 依托单位: University of Fukui
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19689026/
• 关键词: 放射線治療学; 内用放射線治療; オージェ電子; 癌; 分子標的; 分子イメージング

The production of Br-77 was achived using small medical cycltoron. The thymidine derivative radiolabeled with Br-77 was designed and synthesized for internal radiation therapy using Auger electron. This compoound was incorporated into DNA fraction. After incorporation, the effect of internal radiation with Auger electron was appeared as the supression of cell proliferation. This cell proliferation was induced by the appoptosis in damage cells. Gathering these findings, the internal radiation therapy using Br-77 would be a new promissing therapy for cancer treatment.

Br-77的生产是用小型医用旋流器实现的。本文设计合成了溴-77标记的胸苷衍生物，并将其掺入DNA组分中，用于俄歇电子内照射治疗。掺入后，俄歇电子内照射的效应表现为细胞增殖抑制。这种细胞增殖是由损伤细胞中的apatrimer诱导的。综合以上研究结果，Br-77的内照射治疗有望成为一种新的肿瘤治疗方法。

项目成果

Br-77標識チミジン誘導体に関しては、特許出願の準備中である。

我们目前正在准备 Br-77 标记的胸苷衍生物的专利申请。

Development of radiobromine-labeled thymidine analogue as a tumor proliferation imaging agent

开发放射性溴标记的胸苷类似物作为肿瘤增殖显像剂

• 发表时间: 2010
• 作者: Kiyono Y;et al.
• 通讯作者: et al.

Evaluation of radiobromine-labeled 5-bromo-4'-thio-2'-deoxyuridine as a tumor proliferation imaging agent

放射性溴标记的 5-溴-4-硫代-2-脱氧尿苷作为肿瘤增殖显像剂的评价

• 发表时间: 2010
• 作者: Kiyono Y;et al.
• 通讯作者: et al.

アポトーシス誘導剤

细胞凋亡诱导剂

• 发表时间: 2011

Development of radiobromine-labeled 5-bromo-4'-thio-2'-deoxyuridine as atumor proliferation imaging agent

开发放射性溴标记的 5-溴-4-硫代-2-脱氧尿苷作为肿瘤增殖显像剂

• 发表时间: 2010
• 作者: Kiyono Y;et al.
• 通讯作者: et al.