Development of a new therapeutid agent for internal radiation therapy and monitoring using Auger electron emitting radionuclides

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The production of Br-77 was achived using small medical cycltoron. The thymidine derivative radiolabeled with Br-77 was designed and synthesized for internal radiation therapy using Auger electron. This compoound was incorporated into DNA fraction. After incorporation, the effect of internal radiation with Auger electron was appeared as the supression of cell proliferation. This cell proliferation was induced by the appoptosis in damage cells. Gathering these findings, the internal radiation therapy using Br-77 would be a new promissing therapy for cancer treatment.