Development of boron trace drug with broad molecule pursuit and destructive power by neutron irradiation

中子辐照开发具有宽分子追踪和破坏力的硼微量药物

• 批准号: 24659566
• 负责人: HORI Hitoshi
• 金额: $ 2.33万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659566/
• 关键词: インターベンショナルラジオロジー（ＩＶＲ）; ボロントレースドラッグ; 中性子; クルクミン

The purpose of this research is to development a boron trace drug with broad molecule pursuit and destructive power by neutron irradiation. We performed the destruction of BSA and glycated BSA as a AGE model using boron-modified crucumin UTX-51 and thermal neutron, and pharmacokinetic analysis of UTX-51 by a chicken egg model. It turned out that UTX-51 destroys BSA and the glycated BSA efficiently at the combined with a thermal neutron. Moreover, it revealed that UTX-51 passing through a blood brain barrier and also being distributed in a brain from the pharmacokinetic analysis. Therefore, UTX-51 is more promising as a boron trace drug, and it was suggested that it can become a candidate for Alzheimer's disease.

本研究的目的是研制一种分子追踪性广、杀伤力强的中子辐照痕量硼药物。我们用硼修饰的十字蛋白UTX-51和热中子破坏BSA和糖化的BSA作为年龄模型，并用鸡蛋模型分析了UTX-51的药代动力学。事实证明，UTX-51在与热中子结合时可以有效地破坏BSA和糖化的BSA。此外，药代动力学分析还揭示了UTX-51通过血脑屏障后在脑内的分布。因此，UTX-51作为一种硼的痕量药物更具前景，有人建议它可以成为阿尔茨海默病的候选药物。

项目成果

Boron tracedrug design for neutron dynamic therapeutics for Gc protein as a serum protein-quality-control treatment

用于 Gc 蛋白中子动力学治疗的硼示踪药物设计作为血清蛋白质量控制治疗

• 发表时间: 2013
• 作者: Hitoshi Hori;Ryu Tada;Yoshihiro Uto
• 通讯作者: Yoshihiro Uto

Boron tracedrug design for neutron dynamic therapeutics for LDL

低密度脂蛋白中子动力疗法的硼示踪药物设计

• DOI: 10.1007/978-1-4614-7411-1_51
• 发表时间: 2013
• 期刊: Adv Exp Med Biol
• 作者: Hori H;Nazumi Y;Uto Y
• 通讯作者: Uto Y

Boron tracedrug design for neutron dynamic therapeutics for Gc protein as a serum protein-quality- control treatment

用于 Gc 蛋白中子动力学治疗的硼示踪药物设计作为血清蛋白质量控制治疗

• 发表时间: 2013
• 作者: Matsuda S;et al.;堀均,多田竜,宇都義浩
• 通讯作者: 堀均,多田竜,宇都義浩

Boron tracedrug : design, synthesis, and pharmacological activity of phenolic BODIPY-containing antioxidants as traceable next-generation drug model

硼示踪药物：含 BODIPY 的酚类抗氧化剂作为可追溯的下一代药物模型的设计、合成和药理活性

• DOI: 10.1007/978-1-4614-1566-4_44
• 发表时间: 2012
• 期刊: Adv Exp Med Biol
• 作者: Nakata E;Koizumi M;Yamashita Y;Uto Y;Hori H
• 通讯作者: Hori H

Boron tracedrugs challenge for neutron dynamic therapy

硼示踪药物对中子动力治疗的挑战

• 发表时间: 2012
• 期刊: Anticancer Res
• 影响因子: 2
• 作者: Hori H;Uto Y;Nakata E
• 通讯作者: Nakata E