Study on new tumor imaging by cell labelling method

细胞标记法新型肿瘤成像研究

• 批准号: 24659571
• 负责人: NAKAGAMI Yoshihiro
• 金额: $ 2.33万
• 依托单位: National Center of Neurology and Psychiatry
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659571/
• 关键词: 細胞標識; cell-in-cell活性; 分子生物学的標識

In late years the report about special T cell "HOZOT cell" with the property that a cancer cell specifically attracted was accomplished. Using HOZOT cell, We develop a nuclear medicine diagnostic method with the specificity for a cancer and are intended to aim at the application to the nuclear medicine cure for cancer more in this study. We succeeded in labelling HOZOT cell with indium-111, and I administered this intravenously to the mice with human breast cancer, and we imaged them with SPECT-CT device for animals, but unfortunately the accumulation of the HOZOT cell only was diffusely seen in the whole both lungs, and had little meaningful accumulation to the cancer organization. We could label HOZOT cell by nuclides except indium-111 and want to enable the imaging of a cancer with them in future.

近年来完成了关于具有特异性吸引癌细胞的特性的特殊T细胞“HOZOT细胞”的报道。利用HOZOT细胞，我们开发了一种对癌症具有特异性的核医学诊断方法，本研究旨在更多地应用于癌症的核医学治疗。我们成功地用铟-111标记HOZOT细胞，我将其静脉注射给患有人乳腺癌的小鼠，并用动物SPECT-CT设备对其进行成像，但不幸的是，HOZOT细胞的积聚仅在整个双肺中弥漫可见，对癌组织几乎没有有意义的积聚。我们可以用除铟-111以外的核素标记HOZOT细胞，并希望在未来能够用它们对癌症进行成像。

项目成果

FDG-PET/CT imaging to monitor the response of esophagus cancer to proton-beam therapy

FDG-PET/CT 成像监测食道癌对质子束治疗的反应

• 发表时间: 2013
• 作者: Zenda S;Nakagami Y;Toshima M;Arahira S;Kawashima M;Matsumoto Y,Kinoshita H;Satake M;Akimoto T.;Nakagami Y,Kobayashi T,Ogawa T,Hara T,Satake M
• 通讯作者: Nakagami Y,Kobayashi T,Ogawa T,Hara T,Satake M