Pathogenesis of bleb formation in idiopathic pneumothorax

特发性气胸中气泡形成的发病机制

• 批准号: 24659636
• 负责人: TAKEDA Yuji
• 金额: $ 2.08万
• 依托单位: Saga University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659636/
• 关键词: ブレブ形成; 自然気胸; 遺伝子解析; ブレブ; ウィルス

Purpose: The Bleb, which can cause spontaneous pneumothorax development. We conducted a study in order to identify the presence of a specific pathogen in the formation of the Bleb. Method: From the lungs excised during spontaneous pneumothorax surgery, by extracting RNA and DNA, was subjected to gene search using a sensitive exhaustive search method pathogens.Result: Such as TTV, HHV-6, HHV-7, EBV, parvovirus B19 were detected from Bleb part. But these viruses are detected from the normal lung tissue, except parvovirus B19. Relevance of bleb formation and these pathogens unknown at this time. Conclusion: Identification of specific pathogens were unable to Bleb tissue that could be the pathogenesis of pneumothorax.

目的：引起自发性气胸的BLEB。我们进行了一项研究，以确定在Bleb的形成中存在一种特定的病原体。方法：从自发性气胸手术切除的肺组织中提取RNA和DNA，用灵敏的穷举搜索法进行基因搜索。结果：从肺组织中检出TTV、HHV-6、HHV-7、EBV、B19等病毒。但除了细小病毒B19外，这些病毒都是从正常肺组织中检测到的。滤过泡的形成与这些病原体的相关性目前尚不清楚。结论：无法鉴定特定病原体的组织，这可能是气胸的发病机制。