Establishment of arteriosclerosis index related with leukocyte and platelet function measured by whole blood analysis method

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Increase in myocardial and cerebral infarction caused by arteriosclerosis is an importantissue in Japan, since the Japanese population is aging faster than any other in the world.Recently, pathology of arteriosclerosis is known as chronic inflammation of an arterial wall.However, there is no arteriosclerosis index using the function of leukocyte and platelet,which induce the progression of arteriosclerosis via inflammatory responses. In this study,the cell functions were measured in the model of diabetes, hyperlipidemia and turbulentblood flow, which are risk factors for arteriosclerosis, to examine whether the cell functions can be used for a new index of arteriosclerosis. The phagoytic activity of monocyte andgranulocyte were down-regulated in the diabetes and hyperlipidemia. Furthermore, a platelet-monocyte complex formation was selectively increased by turbulent blood flow.Therefore, these functional changes will be useful for an index to prevent the progression ofarteriosclerosis by an early intervention.