Pharmacological analysis of antispasmogenic with wire myograph

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To avoid the vascular spasm during microvascular surgery for free tissue transfer, lidocaine has been widely used. On the other hand, the proper concentration of lidocaine is unknown. We introduced wire-myograph system for pharmacological and physiological analysis of lidocaine or other substances for its anti-spasmogenic activity. We examined papaverine hydrochloride, phentolamine messmate, olprinone hydrochloride, nitroglycerine, and prostaglandin E1. On the result, those substances, except prostaglandin E1, showed concentration-dependent anti-spasmogenic activity. On the other hand, prostaglandin E1 showed concentration-dependent spasmogenic activity which may be caused by inflammatory activity. In conclusion, those substances may be used for anti-spasmogenic agent during microsurgical operation.