Role of oral bacteria on hepatitis

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We investigated the role of oral bacteria-related substances on the development of nonalcoholic steatohepatitis (NASH). We found that P. gingivalis-related substances such as lipopolysaccharide (LPS) induced the pathogenesis of NASH on mice under high-fat diet condition. We found the potential mechanisms about the high-fat diet-induced and LPS-stimulated NASH on mice like that leptin-mediated hypersensitivity against LPS was involved in the mechanism. These findings are very important for the prevention of NASH, and we reported such findings to many high-level journals such as "Cell Metabolism".