Investigation into the mechanism in the development of disorder of masticatory and swallowing centers using time and brain-specific conditional knockout mice

利用时间和脑特异性条件敲除小鼠研究咀嚼和吞咽中枢紊乱的发生机制

• 批准号: 24659913
• 负责人: YOSHIDA Noriaki
• 金额: $ 2.41万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659913/
• 关键词: 顎運動; 筋電図; 咀嚼機能; 嚥下機能; 顎口腔機能; 咀嚼中枢; 摂食中枢; 神経伝達物質; 嚥下中枢

In order to elucidate the etiology of masticatory or feeding disorders,jaw-movement trajetories and the relevant muscles' activities during mastication and swallowing were recorded in mice expressing disorder of neural transmission. As a result, it was suggested that the central masticatory or swallowing pattern generator was impaired, and then sensory feed-back system,which modulates the relevant muscles' activities depending on the food consistency.The investigation into the role of neural transmitter in regulatory mechanism of masticatory and swallowing system would lead to the development of chemotherapy for masticatory or feeding disorders.

为了阐明咀嚼或进食障碍的病因，记录了表现为神经传递障碍的小鼠在咀嚼和吞咽过程中的下颌运动轨迹和相关肌肉的活动。结果表明，中枢咀嚼或吞咽模式生成器受损，进而导致感觉反馈系统受损，感觉反馈系统根据食物的浓度调节相关肌肉的活动。研究神经递质在咀嚼和吞咽系统调节机制中的作用将为治疗咀嚼或进食障碍的化疗提供依据。

项目成果

Effect of bracket slot and archwire dimensions on anterior tooth movement during space closure in sliding mechanics: A three-dimensional finite element study

滑动力学中间隙闭合过程中托槽槽和弓丝尺寸对前牙移动的影响：三维有限元研究

• 发表时间: 2014
• 期刊: Am J Orthod Dentofac Orthop
• 作者: Tominaga J;Ozaki H;Chiang PC;Sumi M;Tanak M;Koga Y;Bourauel C;Yohida N
• 通讯作者: Yohida N

軟食化モデルマウスにおける咀嚼機能発達とキャッチアップに関する実験的研究

软食模型小鼠咀嚼功能发育及追赶的实验研究

• 发表时间: 2013
• 作者: Fujishita A;Nakamura A;Utsumi D;Tanaka M;Koga Y;Yoshida N;藤下あゆみ,中村文,内海大,田中基大,古賀義之,吉田教明;藤下あゆみ,中村文,内海大,田中基大,古賀義之,吉田教明
• 通讯作者: 藤下あゆみ,中村文,内海大,田中基大,古賀義之,吉田教明

咀嚼機能の発達過程において臨界期は存在するか？

咀嚼功能的发育过程中是否存在关键期？

• 发表时间: 2013
• 作者: Fujishita A;Nakamura A;Utsumi D;Tanaka M;Koga Y;Yoshida N;藤下あゆみ，中村文，内海大，田中基大，古賀義之，吉田教明;藤下あゆみ，中村 文，内海 大，田中基大，古賀義之，吉田教明
• 通讯作者: 藤下あゆみ，中村 文，内海 大，田中基大，古賀義之，吉田教明

Experimental investigation into development and catch-up of masticatory function,

咀嚼功能发育和追赶的实验研究，

• 发表时间: 2013
• 作者: Fujishita A;Nakamura A;Utsumi D;Tanaka M;Koga Y;Yoshida N
• 通讯作者: Yoshida N

A possible synaptic configuration underlying coeruleospinal inhibition of visceral nociceptive transmission in the rat.

蓝脊髓抑制大鼠内脏伤害性传递的可能的突触结构。

• DOI: 10.1007/s10072-011-0739-5
• 发表时间: 2012
• 期刊: Neurol Sci.
• 作者: Hayashi B;Tsuruoka M;Maeda M;Tamaki J;Inoue T.
• 通讯作者: Inoue T.