Analysis of multiple odontoma in the patients

牙瘤是由牙源性硬组织和软组织混合而成的错构瘤。牙瘤是颌骨中最常见的牙源性肿瘤。然而，在同一患者中发生多个牙瘤的情况很少见。我们在此报告两位多发性牙瘤患者。这两位患者在所有磨牙的根尖都有复合型和复合型牙瘤。显微镜检查不仅显示了牙瘤的牙本质管和牙骨质的异常结构，而且还显示了拔除牙齿的异常结构。由于这两个多发性牙瘤患者的临床特征似乎相对一致，我们使用CGH阵列进行了基因分析。这些数据表明，牙齿的结构异常和多发性牙瘤的发生是由特定基因引起的。

Odontomas are hamartoma composed of a mixture of odontogenic hard and soft tissues. Odontomas are the most common of the odontogenic tumors in the jaw. However it is a rare case that multiple odontoma occurs in the same patient. Here we report two patients of multiple odontomas. These two patients have both of the compound and complex type odontoma at the root apical of all molars. Microscopic examination showed the unusual structure of dentin tubes and cementum of not only odontoma but also extracted tooth. Because the clinical features of these two patients with multiple odontoma seem to be relatively consistent, we performed the gene analysis using CGH array. These data suggested that the structural abnormalities of the tooth and the occurrence of multiple odontomas are caused by specific genes.