Event-binding and coprolalic tics

本项目调查图雷特综合症的一个特征，伴侧抽动。它的主要目的是测试在正常语言中的辅助语态抽搐和在一定程度上也包括咒骂/咒骂是否优先集成到所谓的事件文件中（与中性词相比），从而在某些情况下快速和准自动地产生这些话语或抽搐。该项目的目的是证明将辅助抽搐和诅咒优先整合到事件文件中，正如Hommel所定义的那样，并且与典型的发展对照相比，在图雷特综合征患者中，这种辅助抽搐/诅咒事件文件的绑定更强。为此，我们使用功能磁共振成像（fMRI）和基于功能磁共振成像（fMRI）的连通性测量来描述辅助语词/诅咒事件文件绑定的神经网络。我们还将描述事件文件绑定的神经生理机制，涉及使用脑电图伴侧抽搐和诅咒。这将考虑对诅咒和协语的显式和隐式处理的操纵，以及在事件文件绑定方面自我相关和其他相关话语之间潜在差异的表征。

This project investigates a characteristic feature of Tourette’s syndrome, coprolalic tics. Its main objective is to test whether coprolalic tics and to a certain degree also curses / expletives in normal language are preferentially integrated into so-called event files (compared to neutral words) allowing for a rapid and quasi-automatic production of these utterances or tics in certain situations. The project aims to demonstrate a preferential integration of coprolalic tics and curses into event files, as they have been defined by Hommel, and a stronger binding of such coprolalia/cursing event files in patients with Tourette’s syndrome compared to typically developing controls. Doing so, we delineate the neural network underlying coprolalia/cursing event file binding using fMRI and fMRI-based connectivity measures. We will also characterize the neurophysiological mechanisms of event file binding with regard to coprolalic tics and curses using EEG. This will be done considering manipulations of explicit and implicit processing of curses and coprolalic tics, as well as the characterization of the potential difference between self-related and other-related utterances with regard to event file binding.