Event-binding and coprolalic tics

事件绑定和粪便抽动

• 批准号: 396579241
• 负责人: Professor Dr. Thomas F. Münte
• 金额: --
• 依托单位: Klinik für Neurologie
• 依托单位国家: 德国
• 项目类别: Research Units
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/396579241?language=en
• 关键词: Event; binding; coprolalic; tics

This project investigates a characteristic feature of Tourette’s syndrome, coprolalic tics. Its main objective is to test whether coprolalic tics and to a certain degree also curses / expletives in normal language are preferentially integrated into so-called event files (compared to neutral words) allowing for a rapid and quasi-automatic production of these utterances or tics in certain situations. The project aims to demonstrate a preferential integration of coprolalic tics and curses into event files, as they have been defined by Hommel, and a stronger binding of such coprolalia/cursing event files in patients with Tourette’s syndrome compared to typically developing controls. Doing so, we delineate the neural network underlying coprolalia/cursing event file binding using fMRI and fMRI-based connectivity measures. We will also characterize the neurophysiological mechanisms of event file binding with regard to coprolalic tics and curses using EEG. This will be done considering manipulations of explicit and implicit processing of curses and coprolalic tics, as well as the characterization of the potential difference between self-related and other-related utterances with regard to event file binding.

本项目研究抽动秽语综合征的一个特征，粪吐抽搐。其主要目的是测试在正常语言中的粪吐抽搐和在一定程度上的诅咒/咒骂是否优先集成到所谓的事件文件中（与中性词相比），从而允许在某些情况下快速和准自动地产生这些话语或抽搐。该项目的目的是证明一个优惠的整合粪抽搐和诅咒的事件文件，因为他们已经被定义的Hommel，和一个更强的约束力，这样的粪/诅咒事件文件在抽动秽语综合征患者相比，通常发展控制。这样做，我们描绘的神经网络基础coprolalia/诅咒事件文件绑定使用功能磁共振成像和功能磁共振成像为基础的连接措施。我们还将使用脑电图描述事件文件绑定的神经生理学机制。这将考虑操纵的诅咒和coprolalic抽搐的显式和隐式处理，以及表征的潜在差异之间的自我相关和其他相关的话语事件文件绑定。