A pilot study for visualizing diurnal hormonal secretion pattern within a hair

一项可视化头发内昼夜荷尔蒙分泌模式的初步研究

• 批准号: 25540122
• 负责人: NOMURA Shusaku
• 金额: $ 2.41万
• 依托单位: Nagaoka University of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25540122/
• 关键词: ストレス; 感性生理学; 実験系心理学; 感性情報学

The hormones shows a characteristic diurnal secretion pattern, the higher in the morning and lower in the evening. This diurnal hormonal secretion in the blood might be recorded within a hair just like as "an annual ring of tree," because the hair growth, which is about 0.3 mm every day, is involved one of the most active cellular activity in the body. The challenge of this study is to visualize this diurnal pattern by using biochemical analysis, such as protein staining and immunostaining. This objective has yet to be achieved so far. However, there accumulated the techniques and knowledge to reach a final goal, such as development of making hair section technique and protein staining procedure for the hair section, and observation of detailed hormonal diurnal patter, especially during night through morning.

激素显示出特征性的昼夜分泌模式，早上较高，晚上较低。血液中的这种昼夜激素分泌可能会记录在头发中，就像“树木的年轮”一样，因为头发的生长，每天约0.3毫米，涉及体内最活跃的细胞活动之一。这项研究的挑战是通过使用生物化学分析，如蛋白质染色和免疫染色来可视化这种昼夜模式。这一目标迄今尚未实现。然而，积累了技术和知识以达到最终目标，例如开发了毛发切片制作技术和毛发切片的蛋白质染色程序，并观察了详细的激素昼夜模式，特别是在夜间到早晨。

项目成果

An impact of the awakening on the secretion of the HPA- and the SAM-related substances in saliva

觉醒对唾液中 HPA 和 SAM 相关物质分泌的影响

• 发表时间: 2013
• 作者: Shusaku Nomura;Kazumichi Suguri;and Masako Hasegawa-Ohira
• 通讯作者: and Masako Hasegawa-Ohira

Increased cortisol secretion after awakening following lavender inhalation during sleep

睡眠时吸入薰衣草后醒来后皮质醇分泌增加

• 发表时间: 2013
• 作者: Shusaku Nomura;Masako Hasegawa- Ohira;Toyonari Fujikawa;and Kanetoshi Ito
• 通讯作者: and Kanetoshi Ito