Changes of DNA profile in canine granular tumor cells transformed to melanoma cells

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Gene profile was examined in 3 passages of granular cell tumor (GCT), 3 masses developed on nude mouse with GCT and 3 established malignant melanoma cells from oral, neil bed and ocular. Genes related to cell proliferation signaling pathway (PI3K, MAPK, PPAR) and pathways in cancer were significantly increased in GCT with advanced passages, whereas genes related to oxidative phosphorylation were significantly decreased. Significant increase of genes related to cell proliferation signaling pathway (VEGF etc), pathways in cancer, gap and tight junction, and oxidative phosphorylation were observed in developed mass with advanced weeks. In addition, gene profile in ocular melanoma cell was quite different from another 2 cells, showing significant higher expression of genes related to cell proliferation signaling pathway (PI3K), pathways in cancer, gap and tight junction, and lower expression of genes related to cell proliferation signaling pathway, melanogenesis, and melanoma.