Investigative studies on the effect of moxibustion on Parkinson's disease

艾灸治疗帕金森病疗效的调查研究

• 批准号: 25670360
• 负责人: ATSUZAWA Kimie
• 金额: $ 2.41万
• 依托单位: Fujita Health University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25670360/
• 关键词: 東洋医学; 施灸; ドパミン分泌; パーキンソン病

The effect of moxibustion on normal and Parkinson's disease model animals were attempted to show its effects on dopamine secretion, motor and other symptoms. The moxibustion on normal rats resulted in the secretion of dopamine and c-fos expression in the striatum, also made the locomotor activity higher. The synthetic activity of dopamine shown by the presence of tyrosine hydroxylase was made decreased, and c-fos expression in the striatum in the animals administered with 6OHDA to the striatum. This may indicate the dopamine secretion induced by moxibustion regulates the function of the striatum. The body temperature of the animals administered with reserpine was made elevated by moxibustion. These reactions of animals to moxibustion, dopamine secretion in the striatum; its activation by dopamine; increased locomotor activity; and the elevation of the body temperature, were suggested to be effective for the treatment of the symptoms of Parkinson's disease.

通过艾灸对正常及帕金森病模型动物的影响，探讨艾灸对多巴胺分泌、运动及其他症状的影响。艾灸可使正常大鼠纹状体多巴胺分泌增加，c-fos表达增强，自发活动增强。通过酪氨酸羟化酶的存在显示的多巴胺的合成活性降低，并且在向纹状体施用6 OHDA的动物中纹状体中的c-fos表达降低。这可能说明艾灸引起的多巴胺分泌对纹状体功能有调节作用。艾灸使利血平组动物体温升高。动物对艾灸的这些反应，纹状体中多巴胺的分泌;多巴胺的激活;运动活动的增加;以及体温的升高，被认为对治疗帕金森病的症状有效。

项目成果

施灸による脳反応のc-Fos免疫組織化学による解析

c-Fos 免疫组织化学分析艾灸引起的脑反应

• 发表时间: 2014
• 作者: 深澤元晶;臼田信光;永津郁子;中原大一郎;厚沢季美江;森山陽介
• 通讯作者: 森山陽介

c-Fosの免疫組織化学による施灸反応の脳反応の解析

使用 c-Fos 免疫组织化学分析艾灸的大脑反应

• 作者: 深澤元晶;厚沢季美江;森山陽介;中井さち子;渡仲三;永津郁子;中原大一郎;臼田信光
• 通讯作者: 臼田信光

Expression of the JAK/STAT3/SOCS3 signaling pathway in herniated lumbar discs

• DOI: 10.1016/j.neulet.2014.03.045
• 发表时间: 2014-05-21
• 期刊: NEUROSCIENCE LETTERS
• 影响因子: 2.5
• 作者: Osuka, Koji;Usuda, Nobuteru;Takayasu, Masakazu
• 通讯作者: Takayasu, Masakazu

Different modifications of phosphorylated Smad3C and Smad3L through TGF-β after spinal cord injury in mice

• DOI: 10.1016/j.neulet.2013.05.042
• 发表时间: 2013-08-09
• 期刊: NEUROSCIENCE LETTERS
• 影响因子: 2.5
• 作者: Joko, Masahiro;Osuka, Koji;Takayasu, Masakazu
• 通讯作者: Takayasu, Masakazu

施灸によるc-Fos発現の免疫組織化学的研究

艾灸对c-Fos表达的免疫组织化学研究

• 发表时间: 2013
• 作者: 深澤元晶;臼田信光;森山陽介;永津郁子;中原大一郎;厚沢季美江
• 通讯作者: 厚沢季美江