Human iPS-derived hepatocyte-like progenitor cells susceptible for hepatitis B virus infection
Human iPS-derived hepatocyte-like progenitor cells susceptible for hepatitis B virus infection
批准号:
25670366
负责人:
ASAHINA Yasuhiro
金额:
$2.41万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2013
资助国家:
日本
项目状态:
已结题
起止时间:
2013-04-01 至 2015-03-31
中文摘要
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英文摘要
期刊论文(29)
专著(0)
科研奖励(0)
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Serum interleukin-6 levels during treatment correlate with resistance to telaprevir-based triple therapy in chronic hepatitis C
治疗期间血清白细胞介素 6 水平与慢性丙型肝炎对基于特拉匹韦的三联疗法的耐药性相关
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Asahina Y, Sakamoto N, et al, Asahina Y]
通讯作者:
Asahina Y
Impact of host and therapeutic factors and resistant associated variants on response to interferon based- direct acting antiviral treatment in difficult-to-treat chronic hepatitis C patients.
宿主和治疗因素以及耐药相关变异对难治性慢性丙型肝炎患者基于干扰素的直接作用抗病毒治疗的影响。
DOI:
--
发表时间:
2014
期刊:
影响因子:
--
作者:
[Nakagawa M, Asahina Y, Taniguchi M, Watanabe T, Nishimura-Sakurai Y, Itsui Y, Azuma S, Kakinuma S, Tanaka Y, Watanabe M.]
通讯作者:
Watanabe M.
Clinical Characteristics of Patients who Developed Hepatocellular Carcinoma after Hepatitis C Virus Eradication with Interferon Therapy: Current Status in Japan
用干扰素治疗根除丙型肝炎病毒后发展为肝细胞癌的患者的临床特征:日本现状
DOI:
10.2169/internalmedicine.52.1180
发表时间:
2013
期刊:
Internal Medicine
影响因子:
1.2
作者:
[Sato A, SataM, Ikeda K, Kumada T, Izumi N, Asahina Y, Osaki Y, Chayama K, Kaneko S, Sakai A, Onji M, Hiasa Y, Omura T, Ozeki I, Yokosuka O, Shiina S, Itsubo M, Nishiguchi S, Hirano K, Ide T, Sakisaka S, Yamasaki T, Hidaka I, Tanaka M, Kim SR, Ichida T.]
通讯作者:
Ichida T.
Expression of IFN/.4 in liver and PBMC is closely associated with higher basal expression of ISGs and impaired induction of IL28B by interferon treatment in chronic hepatitis C non-responder patients.
肝脏和 PBMC 中 IFN/.4 的表达与 ISG 基础表达升高以及慢性丙型肝炎无反应患者干扰素治疗导致的 IL28B 诱导受损密切相关。
DOI:
--
发表时间:
2014
期刊:
影响因子:
--
作者:
[Murakawa M, Asahina Y, Nakagawa M, Sakamoto N, Nitta S, Kawai-Kitahata F, Taniguchi M, Watanabe T, Itsui Y, Kakinuma S, Watanabe M.]
通讯作者:
Watanabe M.
Impaired IL28B gene induction and expression of IFNλ4 influenced by the polymorphisms near IL28B gene are closely associated with a non-response to interferon in chronic hepatitis C patients.
IL28B 基因附近多态性影响的 IL28B 基因诱导和 IFNλ4 表达受损与慢性丙型肝炎患者对干扰素无反应密切相关。
DOI:
--
发表时间:
2014
期刊:
影响因子:
--
作者:
[Asahina Y, Murakawa M, NittaS, Itsui Y, Nakagawa M, Azuma S, Kakinuma S, Watanabe M.]
通讯作者:
Watanabe M.
共 18 条
Association of gene expression involving innate immunity and genetic variation in IL28B with antiviral response
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批准号:20590769
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2008
-
负责人:ASAHINA Yasuhiro
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依托单位:
Pathogenesis of chronic hepatitis C and hepatocellular carcinoma and predictive factors determined by data mining
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批准号:18590724
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.57万
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财政年份:2006
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负责人:ASAHINA Yasuhiro
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依托单位:
海外基金