Contribution of mitochondrioa to keratinization

线粒体在包括细胞死亡在内的许多细胞过程中起着关键作用。最近，有报道称线粒体裂变/融合过程对细胞死亡很重要。线粒体形态受几种gtpase调控：融合由mitofusin 1 （Mfn1）和Mfn2介导。适当的线粒体动力学对人类健康至关重要。角化需要严格调节角质细胞增殖和细胞死亡。然而，线粒体在角化中的作用仍然不清楚。我们发现角质形成细胞中的线粒体分布在核周区域。基底细胞和上基底细胞的线粒体形态无差异。然而，每个细胞的线粒体数量在基底上细胞明显高于基底细胞。我们发现Mfn1和Mfn2的表达模式有很大的不同：Mfn1在基底上细胞中表达，而Mfn2只在基底细胞中表达。

Mitochondria play critical roles in many cellular processes, including cell death. Recently, it is reported that mitochondrial fission/fusion processes are important for cell death. Mitochondrial morphologies are regulated by several GTPases: fusion is mediated by mitofusin 1 (Mfn1) and Mfn2. Proper mitochondrial dynamics are critical for human health.Keratinization requires strict regulation of keratinocyte proliferation and cell death. However, the role of mitochondria in keratinization remains obscure. We showed that mitochondria in keratinocyte cells were distributed in the perinuclear regions. No difference in mitochondrial morphology between the basal and the suprabasal cells. However, the number of mitochondria per cell was significantly higher in the suprabasal cells than in the basal cells. We found that the expression patterns of Mfn1 and Mfn2 were quite different: Mfn1 was expressed in the suprabasal cells, whereas Mfn2 was expressed only in the basal cells.