Contribution of mitochondrioa to keratinization

线粒体对角化的贡献

• 批准号: 25670495
• 负责人: ABE Riichiro
• 金额: $ 2.41万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25670495/
• 关键词: ミトコンドリア; 角化

Mitochondria play critical roles in many cellular processes, including cell death. Recently, it is reported that mitochondrial fission/fusion processes are important for cell death. Mitochondrial morphologies are regulated by several GTPases: fusion is mediated by mitofusin 1 (Mfn1) and Mfn2. Proper mitochondrial dynamics are critical for human health.Keratinization requires strict regulation of keratinocyte proliferation and cell death. However, the role of mitochondria in keratinization remains obscure. We showed that mitochondria in keratinocyte cells were distributed in the perinuclear regions. No difference in mitochondrial morphology between the basal and the suprabasal cells. However, the number of mitochondria per cell was significantly higher in the suprabasal cells than in the basal cells. We found that the expression patterns of Mfn1 and Mfn2 were quite different: Mfn1 was expressed in the suprabasal cells, whereas Mfn2 was expressed only in the basal cells.

线粒体在许多细胞过程中起关键作用，包括细胞死亡。最近，据报道，线粒体分裂/融合过程是重要的细胞死亡。线粒体形态由几种GTP酶调节：融合由线粒体融合蛋白1（Mfn 1）和Mfn 2介导。正常的线粒体动力学对人类健康至关重要，角质化需要严格调控角质细胞的增殖和细胞死亡。然而，线粒体在角化中的作用仍然不清楚。结果表明，角质形成细胞的线粒体分布于核周区。基底细胞和基底上细胞的线粒体形态无差异。然而，每个细胞中的线粒体数量显着高于在基底细胞中的suprabasal细胞。我们发现，Mfn 1和Mfn 2的表达模式是完全不同的：Mfn 1在基底上细胞中表达，而Mfn 2仅在基底细胞中表达。

项目成果

The mitochondria fusion proteins Mfn1 and Mfn2 are involved in keratinization

线粒体融合蛋白 Mfn1 和 Mfn2 参与角化

• 发表时间: 2013
• 作者: Asuka Suto;Riichiro Abe
• 通讯作者: Riichiro Abe

The mitochondrial fusion proteins Mfn1 and Mfn2 are involved in keratinocytes

线粒体融合蛋白 Mfn1 和 Mfn2 参与角质形成细胞

• 发表时间: 2013
• 作者: Asuka Suto;Riichiro Abe;Asuka Suto
• 通讯作者: Asuka Suto