Regenerative medical therapy using bone marrow derived cells

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Recent studies have suggested that bone marrow cells transdifferentiate to a variety of cellular lineages including skin. Investments for regenerative medicine have been used respective model mouse as a preclinical step. In our study, we conducted basic research to achieve radical cure for epidermolysis bullosa to which there is no effective therapy.First as a basic research step, we demonstrated the existence of the factors secreted from keratinocytes that induces transdifferentiation from bone marrow derived cells into keratinocyte. Next as a preclinical step, bone marrow transplantation from normal mouse to type XVII collagen knock out mouse, one of the epidermolysis bullosa model mouse, induced production of the defect protein (XVII type collagen) and improvement of clinical manifestation of the mouse. So we suggested that the bone marrow transplantation from normal mouse to model mouse can be one of the effective therapies for epidermolysis bullosa..