Regenerative medical therapy using bone marrow derived cells

使用骨髓来源的细胞进行再生医学治疗

• 批准号: 20591332
• 负责人: ABE Riichiro
• 金额: $ 3.16万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591332/
• 关键词: 皮膚炎症; 再生学; 皮膚生理学; 皮膚性理学

Recent studies have suggested that bone marrow cells transdifferentiate to a variety of cellular lineages including skin. Investments for regenerative medicine have been used respective model mouse as a preclinical step. In our study, we conducted basic research to achieve radical cure for epidermolysis bullosa to which there is no effective therapy.First as a basic research step, we demonstrated the existence of the factors secreted from keratinocytes that induces transdifferentiation from bone marrow derived cells into keratinocyte. Next as a preclinical step, bone marrow transplantation from normal mouse to type XVII collagen knock out mouse, one of the epidermolysis bullosa model mouse, induced production of the defect protein (XVII type collagen) and improvement of clinical manifestation of the mouse. So we suggested that the bone marrow transplantation from normal mouse to model mouse can be one of the effective therapies for epidermolysis bullosa..

最近的研究表明，骨髓细胞转分化为各种细胞谱系，包括皮肤。对再生医学的投资已被用于各自的模型小鼠作为临床前步骤。为了彻底治愈目前尚无有效治疗方法的大疱性表皮病，本研究进行了基础研究。首先，作为基础研究的一步，证明了存在从骨髓来源的细胞向角质形成细胞诱导转分化的角质形成细胞分泌的因子。接下来，作为临床前步骤，将正常小鼠的骨髓移植到大疱性表皮病模型小鼠之一的XVII型胶原基因敲除小鼠中，诱导缺陷蛋白（XVII型胶原）的产生并改善小鼠的临床表现。提示正常小鼠骨髓移植治疗大疱性表皮病是有效的治疗方法之一。

项目成果

A novel DNA vaccine-targeting macrophage migration inhibitory factor improves the survival of mice with sensis

一种新型DNA疫苗靶向巨噬细胞迁移抑制因子可提高敏感小鼠的存活率

• 发表时间: 2008
• 期刊: Gene Therapy 15
• 作者: Sasaki M;Abe R;Fujita Y;Ando S;Inokuma D;Shimizu H.;Tohyama S
• 通讯作者: Tohyama S

Bone marrow transplantation restores epidermal basement membrane protein expression and rescues epidermolysis bullosa model mice

• DOI: 10.1073/pnas.1000044107
• 发表时间: 2010-08-10
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Fujita, Yasuyuki;Abe, Riichiro;Shimizu, Hiroshi
• 通讯作者: Shimizu, Hiroshi

骨髄幹細胞を用いた再生医療

使用骨髓干细胞的再生医学

• 发表时间: 2009
• 作者: Qiao H;et.al.;T. Nakanishi,T. Osaka;阿部理一郎
• 通讯作者: 阿部理一郎

Bone Marrow-Derived Cells Are Not the Origin of the Cancer Stem Cells in Ultraviolet-Induced Skin Cancer

• DOI: 10.2353/ajpath.2009.080362
• 发表时间: 2009-02-01
• 期刊: AMERICAN JOURNAL OF PATHOLOGY
• 影响因子: 6
• 作者: Ando, Satomi;Abe, Riichiro;Shimizu, Hiroshi
• 通讯作者: Shimizu, Hiroshi

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