Genomic aberrations by chemoradiotherapy in children and its transfer to next generation

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To analyze the genomic transmission from the childhood cancer survivors to their future generation, pre- and post-therapeutic genomes in the 26 pairs of the patients and their children were examined using Cytoscan microarray which had more than 2,700,000 SNP (single nucleotide polymorphism) signals. All cases showed mutation, deletion, and insertion in 43 -3,123 (mean 623) loci in their genome and the numbers of altered loci is more in the patients who received radiotherapy. These genomic aberrations were significantly correlated with the use of anthracyclin chemotherapy.In the analysis of their childhood genomes in the comparison with each parent genome, transferred aberrations were suspected in 3 of 24 pairs and all 3 cases were derived from female survivors. From these data, some of these aberration in the survivors were transmitted to the next generation.