Surveillance of current incidence and infrastructure development of international collaboration for childhood liver cancers by Japanese study group for pediatric liver tumor

我们主要在欧洲（SIOPEL）和北美（COG）对肝母细胞瘤病例进行了海外研究，肝母细胞瘤占所有儿科肝脏肿瘤的80%以上。在日本，发病率高于这些国家，但病理学上小的未分化肿瘤的发病率较低。根据患者的结局，我们将肝母细胞瘤患者分为三个风险组：标准，中等和高风险，并为每组提出新的治疗方案。我们还建立了一个新的病理分类方案和注册数据库，为临床试验基础设施开发的国际合作铺平了道路。

We conducted overseas research, mainly in Europe (SIOPEL) and North America(COG), on cases of hepatoblastoma, which account for over 80% of all pediatric liver tumors.. In Japan, the rate of incidence was higher than in these countries, but the incidence of pathologically small undifferentiated tumors was lower.. According to the outcome of the patients, we stratified the hepatoblastoma patients into three risk groups : standard, intermediate, and high risks and proposed new treatment protocols for each group. We also built a new pathological classification scheme and registration database, to pave the way for international collaboration in infrastructure development for clinical trials.