Coupling strategies for planar solid phase extraction with gas chromatography using the example of mineral oil saturated and aromatic hydrocarbons (MOSH and MOAH)

平面固相萃取（pSPE）与气相色谱（GC）联用的基础技术有待发展。pSPE-GC偶联的基础知识通过对包装材料和干燥低脂食品中饱和和芳香族矿物油烃（MOSH和MOAH）进行具有挑战性的痕量分析来研究。将开发和优化两种不同的耦合技术。一方面，pSPE耦合到GC后，洗脱的目标分析物从薄层板，液体注射，另一方面，直接，非歧视性和无损失的耦合热解吸进行了研究。对于这两种策略，多功能且具有成本效益的pSPE用于MOSH和MOAH馏分的预分离，并取代目前使用的LC或SPE预分离。通过pSPE与GC的偶联，pSPE的可接近分析物范围（实际上仅限于LC-可接受的分析物）大大扩展。使用开发的pSPE-GC耦合技术，有效的pSPE概念不仅适用于MOSH/MOAH物质类别，而且还可以对广泛的GC适用物质进行高效，可靠和高选择性的分析，精确定量到痕量水平。另一个目的是开发pSPE，结合光谱检测（UV/FLD），作为一种快速筛选工具，用于直接在薄层板上平行测定食品包装材料、化妆品和干燥低脂食品中的MOSH和MOAH。最后，开发的pSPE，UV/FLD和GC-FID技术相结合，提供了一个有效的，模块化设计的整体分析策略，可用于整个领域的MOSH/MOAH分析，可以很容易地适应进一步的GC适合的物质类别。通过与目前使用的在线LC-GC-FID方法获得的数据进行比较，测试了所开发的pSPE-UV/FLD-GC-FID策略的适用性和真实性。

The fundamental techniques for the coupling of planar solid phase extraction (pSPE) with gas chromatography (GC) should be developed. The basics for the pSPE-GC coupling are studied using the challenging trace analysis of saturated and aromatic mineral oil hydrocarbons (MOSH and MOAH) in packaging materials and dry, low-fat foodstuffs. Two different coupling techniques are to be developed and optimized. On the one hand, pSPE is coupled to GC by liquid injection after the elution of the target analytes from the thin-layer plate, and on the other hand, the direct, non-discriminatory and loss-free coupling by thermal desorption is to be investigated. For both strategies, the versatile and cost-effective pSPE is used for the pre-separation of the MOSH and MOAH fractions and replaces the currently used LC or SPE pre-separation. By the coupling of pSPE to GC, the accessible analyte range for pSPE which actually is limited to LC-amenable analytes, is considerably expanded. Using the developed pSPE-GC coupling techniques, the effective pSPE concept will not only be applicable for the MOSH/MOAH substance classes, but will also allow the efficient, reliable and highly selective analysis for a wide range of GC-amenable substances, with the exact quantitation down to trace levels. A further objective is to develop the pSPE, coupled to spectroscopic detection (UV/FLD), as a fast screening tool for the reliable quantitation of MOSH and MOAH in food packaging materials, cosmetics, and dry, low-fat foods for many samples in parallel directly on the thin-layer plate. Finally, the developed techniques for pSPE, UV/FLD and GC-FID are combined to offer an efficient, modular designed overall analysis strategy, which can be used for the entire field of MOSH/MOAH analysis and can easily be adapted to further GC-amenable substance classes. The developed pSPE-UV/FLD-GC-FID strategy is tested for its suitability and trueness by comparing the results with data obtained by the currently used on-line LC-GC-FID method.