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Coupling strategies for planar solid phase extraction with gas chromatography using the example of mineral oil saturated and aromatic hydrocarbons (MOSH and MOAH)

以矿物油饱和烃和芳香烃（MOSH 和 MOAH）为例，平面固相萃取与气相色谱的耦合策略

基本信息

批准号：
397558367
负责人：
Privatdozentin Dr. Claudia Oellig
金额：
--
依托单位：
Institut für Lebensmittelchemie (170)
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2018
资助国家：
德国
起止时间：
2017-12-31 至 2021-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/397558367?language=en
关键词：
Coupling strategies planar solid phase

项目摘要

The fundamental techniques for the coupling of planar solid phase extraction (pSPE) with gas chromatography (GC) should be developed. The basics for the pSPE-GC coupling are studied using the challenging trace analysis of saturated and aromatic mineral oil hydrocarbons (MOSH and MOAH) in packaging materials and dry, low-fat foodstuffs. Two different coupling techniques are to be developed and optimized. On the one hand, pSPE is coupled to GC by liquid injection after the elution of the target analytes from the thin-layer plate, and on the other hand, the direct, non-discriminatory and loss-free coupling by thermal desorption is to be investigated. For both strategies, the versatile and cost-effective pSPE is used for the pre-separation of the MOSH and MOAH fractions and replaces the currently used LC or SPE pre-separation. By the coupling of pSPE to GC, the accessible analyte range for pSPE which actually is limited to LC-amenable analytes, is considerably expanded. Using the developed pSPE-GC coupling techniques, the effective pSPE concept will not only be applicable for the MOSH/MOAH substance classes, but will also allow the efficient, reliable and highly selective analysis for a wide range of GC-amenable substances, with the exact quantitation down to trace levels. A further objective is to develop the pSPE, coupled to spectroscopic detection (UV/FLD), as a fast screening tool for the reliable quantitation of MOSH and MOAH in food packaging materials, cosmetics, and dry, low-fat foods for many samples in parallel directly on the thin-layer plate. Finally, the developed techniques for pSPE, UV/FLD and GC-FID are combined to offer an efficient, modular designed overall analysis strategy, which can be used for the entire field of MOSH/MOAH analysis and can easily be adapted to further GC-amenable substance classes. The developed pSPE-UV/FLD-GC-FID strategy is tested for its suitability and trueness by comparing the results with data obtained by the currently used on-line LC-GC-FID method.

开发平面固相萃取(PSPE)与气相色谱(GC)联用的基础技术。通过对包装材料和干燥、低脂食品中饱和和芳香族矿物油碳氢化合物(MOSH和MOAH)的挑战性痕量分析，研究了PSPE-GC耦合的基础。需要开发和优化两种不同的耦合技术。一方面，将目标分析物从薄层板上洗脱下来后，用液体进样将pSPE与GC偶联；另一方面，热解吸法实现直接、非歧视、无损失的偶联。对于这两种策略，通用且经济高效的pSPE被用于MOSH和MOAH组分的预分离，并取代了目前使用的LC或SPE预分离。通过pSPE与GC的偶联，pSPE的可及分析物范围实际上仅限于可用于LC的分析物，这是相当大的扩展。使用开发的pSPE-GC耦合技术，有效的pSPE概念将不仅适用于MOSH/Moah物质类别，而且还将允许对广泛的GC依从性物质进行高效、可靠和高度选择性的分析，并精确定量到痕量水平。另一个目标是开发pSPE与光谱检测(UV/FLD)相结合，作为一种快速筛选工具，用于直接在薄层板上并行检测多个样品，从而可靠地定量食品包装材料、化妆品和干性低脂食品中的MOSH和MOAH。最后，将开发的PSPE、UV/FLD和GC-FID技术结合起来，提供了一种有效的、模块化设计的整体分析策略，该策略可以用于整个MOSH/MOAH分析领域，并且可以很容易地适用于更多的GC-遵从性物质类别。将建立的pSPE-UV/FLD-GC-FID方法与目前使用的在线LC-GC-FID方法得到的数据进行比较，验证了该方法的适用性和真实性。