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Developing therapeutic antibodies for Alzheimer's disease

Developing therapeutic antibodies for Alzheimer's disease
开发阿尔茨海默病的治疗抗体
批准号:
10821560
负责人:
Miao Sun
金额:
$48.96万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
已结题
起止时间:
2023-09-15 至 2024-08-31
关键词:
AD transgenic miceAccelerationAdultAffinityAgreementAlzheimer&aposs DiseaseAlzheimer&aposs disease patientAlzheimer&aposs disease therapeuticAmericanAnimal ModelAnimal TestingAnimalsAntibodiesBindingBiochemicalBiological MarkersBlocking AntibodiesBloodBrainBusinessesCaliforniaClinical TrialsCollaborationsCost of IllnessDataDevelopmentDisease ProgressionDoseDrug KineticsEpitopesExcitatory SynapseFundingFutureGeneticGliosisGlutamatesGrantHalf-LifeHeartHumanImpaired cognitionIn VitroIndividualInfusion proceduresIntravenous BolusKidneyKnock-outLaboratoriesLate Onset Alzheimer DiseaseLeadLegal patentLicensingLiverLungMeasuresMedicalMethodsModelingMorphologyMusNeuronsOutcomePathologicPathway interactionsPenetrationPharmaceutical PreparationsPharmacologyPharmacology StudyPhaseProductionRattusRegulationRiskRodentSerumSignal TransductionSmall Business Innovation Research GrantSolidSpinal CordSynapsesTestingTg2576TherapeuticTherapeutic antibodiesTimeTissue SampleTissuesToxicokineticsUnited StatesUniversitiesVariantWild Type MouseWorkblood-brain barrier penetrationcaregivingcell bankcognitive functioncostcross reactivitydensitydrug candidatedrug distributiondrug efficacyeffective therapyhuman old age (65+)human tissuehumanized antibodyimmunogenicityin vivoinhibitorinterestintravenous administrationintravenous injectionmanufacturemouse modelnonhuman primatenovelnovel strategiesnovel therapeutic interventionnovel therapeuticspharmacologicplanar cell polaritypre-clinicalpreclinical developmentpreclinical studypreservationpreventprofessorreceptorscale upstable cell linesynaptic functiontransgenic model of alzheimer disease

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英文摘要
PROJECT SUMMARY/ABSTRACT Millions of Americans suffer from Alzheimer’s disease and there are currently no therapies available to prevent or slow the progression of the disease. The unmet medical needs of individuals with Alzheimer’s disease result in hundreds of billions of dollars of costs in paid and unpaid caregiving in the United States every year. VersaPeutics is a small business developing novel therapeutics for Alzheimer’s disease. In this Phase I SBIR project we will perform IND enabling preclinical studies to investigate pharmacokinetics and pharmacology profiles of leading drug product. At the conclusion of these studies, we will have met several important milestones that will support further preclinical development of our novel therapeutics for Alzheimer’s disease.
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Toxicology and Efficacy Studies of Intrathecal VersaMab-101 for spinal cord injury treatment
  • 批准号:
    10697262
  • 项目类别:
  • 资助金额:
    $238.06万
  • 财政年份:
    2023
  • 负责人:
    Miao Sun
  • 依托单位:
Pharmacokinetics and efficacy of intrathecal VersaMab-101 delivery foracute spinal cord injury
  • 批准号:
    10484664
  • 项目类别:
  • 资助金额:
    $49.51万
  • 财政年份:
    2022
  • 负责人:
    Miao Sun
  • 依托单位:
Developing therapeutic antibodies for Alzheimer's disease
  • 批准号:
    10484675
  • 项目类别:
  • 资助金额:
    $49.85万
  • 财政年份:
    2022
  • 负责人:
    Miao Sun
  • 依托单位:
海外基金