Cancer – microenvironment interactions in the progression to invasive squamous cell carcinoma (B11*)

癌症 â 发展为侵袭性鳞状细胞癌 (B11*) 过程中微环境的相互作用

• 批准号: 397727910
• 金额: --
• 依托单位: Klinik für Dermatologie und Venerologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/397727910?language=en
• 关键词: Cancer; microenvironment; interactions; progression; invasive

DEB (Dystrophic epidermolysis bullosa, a blistering disease of the skin, caused by collagen VII mutations) is characterized by a high penetrance, early-onset cutaneous squamous cell carcinomas (cSCCs) with aggressive metastasis. B11 will investigate the mechanisms that create an altered microenvironment and how the altered tumor microenvironment contributes to the invasive properties of DEB associated cSCCs.

DEB（营养不良性大疱性表皮细胞癌，一种由胶原VII突变引起的皮肤起泡性疾病）的特征在于高转移率、早发性皮肤鳞状细胞癌（cSCC）和侵袭性转移。B11将研究产生改变的微环境的机制，以及改变的肿瘤微环境如何有助于DEB相关cSCC的侵袭性。