Integrated Co-clinical Analysis of 3-D Tumor Organoids to Target Invasion and Metastasis in Pancreatic Cancer (C09*)

3-D 肿瘤类器官针对胰腺癌侵袭和转移的综合临床联合分析 (C09*)

• 批准号: 397752388
• 金额: --
• 依托单位: Klinik für Innere Medizin I - Hämatologie, Onkologie und Stammzelltransplantation
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/397752388?language=en
• 关键词: Integrated; Co; clinical; Analysis; Tumor

The applicants will exploit a unique and continuously growing collection of 3-D tumor organoids derived from patients undergoing treatment for pancreatic ductal adenocarcinoma (PDAC). The goal of the project is to identify and validate potential biomarkers and therapeutic target structures of the migratory, invasive and metastatic capacity of individual patient-derived tumors based on a combined comprehensive molecular and ex vivo co-clinical functional analysis.

申请人将利用来自接受胰腺导管腺癌（PDAC）治疗的患者的独特且不断增长的3-D肿瘤类器官集合。该项目的目标是基于综合的分子和离体联合临床功能分析，识别和验证个体患者源性肿瘤的迁移、侵袭和转移能力的潜在生物标志物和治疗靶点结构。