The effect of self-compassion on integrated treatment outcomes among veterans with co-occurring AUD and PTSD.

项目摘要/摘要 与单独出现的任何一种障碍相比，共发的酒精使用障碍(AUD)和创伤后应激障碍 创伤后应激障碍(PTSD)的临床和治疗过程更为复杂，给退伍军人带来了巨大的健康负担。 确定改善澳大利亚/创伤后应激障碍综合治疗结果的新机制是公共卫生的优先事项 这与NIAAA的战略目标一致，即通过改进来推进酒精相关疾病的治疗 行为和药物治疗。自我同情是一种认知技能，它可能会促进 有效的AUD/PTSD综合治疗。自我同情被认为是通过利用与生俱来的 照顾系统可以与催产素的亲社会效应相互作用，如安全感和信任感。这个 目前的研究将利用NIAAA赞助的一项正在进行的临床试验，该试验正在检查催产素的疗效 与安慰剂相比，在退伍军人中改善综合行为治疗的结果 澳大利亚/创伤后应激障碍。拟议研究的主要目标是检查两个变量之间的纵向联系 自我同情和治疗结果。第二个目标是检查退伍军人是否有更高的自我 在服用安慰剂的情况下，同情心和催产素的使用效果会好于退伍军人。最后，我们将利用 生态瞬时评估(EMA)捕捉自我同情、酒精 消费和问题严重性，以及真实世界背景下的创伤后应激障碍症状。我们假设自己- 同情心将使对AUD和PTSD症状的反应更具适应性(例如，管理渴望、失误、 不适应思维模式)，从而促进更有效的治疗过程并降低易感性 危险饮酒或故态复萌。这是一个重要而可行的项目，将为 自怜心在退伍军人并发创伤后应激障碍康复中的作用。该项目还将提供 关键的培训经历有助于候选人实现成为一名独立酒鬼的长期目标 研究员。根据建议的奖项，候选人将有机会掌握现存的文学作品 对AUD/PTSD的行为和药物干预；2)获得新的设计和技能 临床试验的实施；3)磨练EMA等自然评估方法的技能；4)进步 纵向数据分析能力；5)通过资助和手稿提高学术生产力 发展。她将通过领导拟议的研究来实现这些精心挑选的培训目标 项目，参与与高技能赞助商的全面指导计划，并参与 精心挑选的教学培训机会方案。培训将在医疗中心进行 南卡罗来纳大学(MUSC)成瘾科学部。MUSC是一家著名的学术医疗机构 该中心以其在酒精研究方面的创新和卓越而闻名。因此，候选人将有权访问 机构和赞助商，具有深厚的历史和对临床酒精研究的承诺。

PROJECT SUMMARY/ABSTRACT Compared to either disorder alone, co-occurring alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) has a more complex clinical and treatment course that imposes significant health burden on veterans. Identifying novel mechanisms to improve integrated AUD/PTSD treatment outcomes is a public health priority that aligns with NIAAA’s strategic goal to advance treatment of alcohol-related conditions through the refinement of behavioral and pharmacological treatments. Self-compassion is a cognitive skill that may facilitate more effective integrated AUD/PTSD treatment. Self-compassion is proposed to function by tapping into an innate care-giving system that could interact with oxytocin’s prosocial effects such as feelings of safety and trust. The current study will leverage an ongoing NIAAA-sponsored clinical trial that is examining the efficacy of oxytocin compared to placebo to improve outcomes in an integrated behavioral treatment among veterans with AUD/PTSD. The primary goal of the proposed study is to examine the bivariate longitudinal associations between self-compassion and treatment outcomes. The secondary goal is to examine whether veterans higher in self- compassion and administered oxytocin will outperform veterans in the placebo condition. Finally, we will utilize ecological momentary assessment (EMA) to capture the associations between self-compassion, alcohol consumption and problem severity, and PTSD symptoms in a real-world context. We hypothesize that self- compassion will enable more adaptive responding to AUD and PTSD symptoms (e.g., managing craving, lapses, maladaptive thinking patterns) thereby promoting a more efficient treatment course and reducing susceptibility to risky alcohol use or relapse. This is an important and feasible project that will provide novel insights into the role of self-compassion in AUD recovery among veterans with co-occurring PTSD. This project will also provide critical training experiences necessary to facilitate the candidate’s long-term goal to be an independent alcohol researcher. Under the proposed award, the candidate will have the opportunity to 1) master the extant literature on behavioral and pharmacological interventions for AUD/PTSD; 2) acquire new skills in the design and implementation of clinical trials; 3) hone skills in naturalistic assessment methods such as EMA; 4) advance longitudinal data analytic capabilities; and 5) increase scholarly productivity through grant and manuscript development. She will accomplish these deliberately selected training goals by leading the proposed research project, engaging in a comprehensive mentorship plan with highly skilled sponsors, and participating in a carefully selected program of didactic training opportunities. The training will be carried out at the Medical University of South Carolina (MUSC) in the Addiction Sciences Division. MUSC is a renowned academic medical center known for its innovative and excellence in alcohol research. Thus, the candidate will have access to an institution and sponsors with a strong history and commitment to clinical alcohol research.