权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Transcatheter Placement of Intraluminal Prosthesis for Thoracic Aorta

经导管胸主动脉腔内假体置入术

基本信息

批准号：
01870057
负责人：
YASUDA Keishu
金额：
$ 5.31万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1991
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-01870057/
关键词：
Shape memory alloy Aortic prosthesis Transformoral placement Sutureless grafting Aortic dissection entry closure entry closure 大動脈瘤の治療内挿型 PTA法

项目摘要

We have developed new aortic prosthesis and its placement system for the purpose of treating aortic anuerysm with minimal invasion. The new prosthesis which we call SAP (Shape memory Aortic Prosthesis) consists of Nitinol stent and polyurethane tube, and is designed in such a configuration that it could be compressed inside a 14Fr catheter in 0 - 5 ﾟC and regain its original shape above 30ﾟC. Intra-aortic sutureless placement of SAP was performed for 10 mongrel dogs. After 1 to 3 months, aortography was done and they were sacrified to examine pahtological changes of their aorta and SAP. There were neither anuerysmal changes nor wall thinning in the host aorta. Microscopic examinations revealed intimal dip where the stents of SAP had compressed, but elastic layer was preserved well.Placement system is composed of delivery catheter, pushing rod, catching catheter and pulling wire. Using this system, transfemoral placement of SAP was successfully demonstrated within 3 dogs and 1 sheep. Moreover we also succeeded in transfemorally closing the entry of Stanford type B aortic dissections created in animal models. It might be possible that the use of SAP could prevent the progression of dissection and aneurysmal changes. The concept of transformoral grafting of aortic prosthesis is attractive. The second generation of SAP with highly biocompatible materials should be developed.

我们开发了新型主动脉假体及其放置系统，旨在以微创方式治疗主动脉瘤。我们称之为 SAP（形状记忆主动脉假体）的新型假体由镍钛合金支架和聚氨酯管组成，其设计结构使其可以在 0 - 5°C 的温度下被压缩在 14Fr 导管内，并在 30°C 以上恢复其原始形状。对 10 只杂种犬进行主动脉内无缝线 SAP 植入。 1至3个月后，进行主动脉造影并处死检查主动脉和SAP的病理变化。宿主主动脉既没有动脉瘤变化，也没有壁变薄。镜检显示SAP支架受压处内膜凹陷，但弹性层保存良好。放置系统由输送导管、推杆、捕捉导管和拉线组成。使用该系统，在 3 只狗和 1 只羊中成功演示了 SAP 的经股动脉放置。此外，我们还成功地经股动脉闭合了在动物模型中创建的斯坦福 B 型主动脉夹层的入口。 SAP 的使用可能可以阻止夹层和动脉瘤变化的进展。主动脉假体转化移植的概念很有吸引力。应开发具有高度生物相容性材料的第二代SAP。