Immunmodulation of cytomegalovirus latency and reactivation by regulatory T cells and dendritic cells (14)

骨髓移植（BMT）后，巨细胞病毒（CMV）感染危及移植受者的生存，因为免疫反应不能有效地预防病毒的发病和清除。我们计划研究调节性T细胞（Tregs），特别是CD8 Tregs，在BMT后小鼠CMV反应中抑制保护性CD8 T细胞的作用。此外，我们将研究树突状细胞（dc）如何促进treg的产生和功能。在BMT和巨细胞病毒感染的背景下，更好地了解Tregs的作用及其与dc的相互作用，对于开发基于细胞的治疗方法具有重要意义。

After bone marrow transplantation (BMT), cytomegalovirus (CMV) infections imperil the survival of transplant recipients as the immune response is not efficient in preventing morbidity and clearance of the virus. We plan to investigate the role of regulatory T cells (Tregs), of CD8 Tregs in particular, in suppression of protective CD8 T cells in response to murine CMV after BMT. Furthermore, we will study how dendritic cells (DCs) contribute to the generation and function of Tregs. An improved understanding of the role of Tregs and their interaction with DCs in the context of BMT and CMV infection is of fundamental importance for the development of cell-based therapeutic approaches.