Immunmodulation of cytomegalovirus latency and reactivation by regulatory T cells and dendritic cells (14)

调节性 T 细胞和树突状细胞对巨细胞病毒潜伏期和再激活的免疫调节 (14)

• 批准号: 398474417
• 金额: --
• 依托单位: Institut für Molekulare Medizin
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/398474417?language=en
• 关键词: Immunmodulation; cytomegalovirus; latency; reactivation; regulatory

After bone marrow transplantation (BMT), cytomegalovirus (CMV) infections imperil the survival of transplant recipients as the immune response is not efficient in preventing morbidity and clearance of the virus. We plan to investigate the role of regulatory T cells (Tregs), of CD8 Tregs in particular, in suppression of protective CD8 T cells in response to murine CMV after BMT. Furthermore, we will study how dendritic cells (DCs) contribute to the generation and function of Tregs. An improved understanding of the role of Tregs and their interaction with DCs in the context of BMT and CMV infection is of fundamental importance for the development of cell-based therapeutic approaches.

骨髓移植（BMT）后，巨细胞病毒（CMV）感染会危及移植受者的生存，因为免疫反应不能有效地预防病毒发病和清除。我们计划研究调节性 T 细胞 (Treg)，特别是 CD8 Tregs，在 BMT 后抑制保护性 CD8 T 细胞响应小鼠 CMV 中的作用。此外，我们将研究树突状细胞 (DC) 如何促进 Tregs 的生成和功能。更好地了解 Treg 的作用及其在 BMT 和 CMV 感染背景下与 DC 的相互作用对于开发基于细胞的治疗方法至关重要。