Regulation cell function by light using LOV photoreceptive module

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Phototropin is a blue light sensor in plant which mediates phototropic response et al., and act as a blue light regulated protein kinase. Using the photoactivation mechanism of kinase in the phototropin, we aim to produce a new animal cell of which physiological responses, cell division and cell differentiation, can be switchable by light illumination through controlling the kinase activity of the key protein kinase involved. We introduced the in vitro analysis system in which the regulation of the key enzyme activity can be studied.