The influence of transcript localization on post-translational modification

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Post-translational modification of protein is important in promoting proper function of protein. In this study, we investigated whether post-translational modification of protein is regulated by mRNA localization or not. Dally-like protein (Dlp) in Drosophila has GPI-anchor which is a type of post-translational modification. And dlp mRNA shows restricted distribution near nucleus in wing disc cells. We changed the localization of dlp mRNA by replacing 3’-noncoding region of dlp with that of wingless which contains apical localization signal. The products translated from mislocalized mRNA did not show proper function and were accumulated in apical region of cells, suggesting that mRNA localization is involved in protein function and probably post-translationalmodification.