Challenges towards the generation of the dream immunosuppressant for the 21stcentury without permanent medication

免疫抑制剂对于移植是必不可少的，但目前的药物存在诸如需要长期用药或有致命副作用的风险等问题。在本研究中，我试图阐明免疫抑制抗体（抗h1抗体）在大鼠耐受性肝移植模型中的作用方式，并证明其在体内的治疗效果。这里我发现免疫抑制抗h1抗体直接作用于T细胞发挥其免疫抑制活性，并且抗h1抗体以调节性T细胞依赖和不依赖的机制抑制T细胞活化。我还表明，抗h1抗体延长同种异体心脏移植大鼠模型的存活时间。

Immunosuppressant is essential for transplantation, but current drug has problems such as the need of permanent medication or the risk of fatal side effects. In the present study, I sought to elucidate the mode of action of immunosuppressive antibody (anti-H1 antibody) induced in a rat model of tolerogeneic liver transplantation, and demonstrate its therapeutic efficacy in vivo. Here I found that the immunosuppressive anti-H1 antibody acted directly on T cells to exert its immunosuppressive activity, and that the anti-H1 antibody suppressed T cell activation in regulatory T cell dependent- and -independent mechanisms. I also showed that the anti-H1 antibody prolonged allograft survival in a rat model of heterotopic heart transplantation.