Elucidation of a novel anti-allergic mechanism of pulverized dietary fiber and its application

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In the present study, I analyzed the mode of anti-allergic mechanism of pulverized dietary fiber, especially focused on konjac glucomannan (KGM) as a model diet. I found that dietary pulverized KGM (PKGM) had beneficial effect on the prevention of atopy-associated autoimmune response as well as on the suppression of nasal mast cell infiltration in the allergic rhinitis. I also found that PKGM supplementation induced T cell tolerance against excessive antigen-specific proliferative response. These results suggest that PKGM acts on multiple immune targets to fulfill its anti-inflammatory potency. I also determined optimal particle size of PKGM to achieve its anti-allergic effect, and generated a trial product of PKGM-supplemented food.