Identification of factors that involved in migration of mesenchymal stem cells to lesions of neurodegenerative diseases

鉴定参与间充质干细胞向神经退行性疾病病变迁移的因素

• 批准号: 23658233
• 负责人: HORIUCHI Motohiro
• 金额: $ 2.5万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23658233/
• 关键词: 骨髄由来間葉系幹細胞; プリオン; 神経変性疾患; 走化性; ケモカイン

In vitro migration assay was carried out to investigate chemoattractive factors for MSCs in the brain lesions of prion-infected mice. In addition, expression of chemokine receptor on MSCs that had been transplanted in the brain of prion-infected mice was analyzed. The combined in vitro and in vivo analyses suggest that CCR3, CCR5, CXCR3 and CXCR4 and their corresponding ligands are involved in the migration of hMSCs to the brain lesions caused by prion propagation.

采用体外迁移实验研究朊病毒感染小鼠脑损伤中对MSCs的化学吸引因素。此外，分析了已移植到朊病毒感染小鼠脑中的MSC上的趋化因子受体的表达。体外和体内联合分析表明，CCR3，CCR5，CXCR3和CXCR4及其相应的配体参与了hMSCs向朊病毒传播引起的脑损伤的迁移。

项目成果

Identification of chemoattractive factors involved in the migration of bone marrow-derived mesenchymal stem cells to brain lesions caused by prions

骨髓间充质干细胞向朊病毒引起的脑损伤迁移的趋化因子的鉴定

• 发表时间: 2011
• 期刊: J. Virol
• 作者: Song C.-H.;Honmou;O.;Furuoka;H. and Horiuchi;M
• 通讯作者: M

プリオンの感染と細胞内動態

朊病毒感染和细胞内动力学

• 发表时间: 2013
• 期刊: Dementia Japan
• 作者: 山﨑 剛士;堀内 基広
• 通讯作者: 堀内 基広

Characterization of prion infection in differentiated mouse neurospheres

分化小鼠神经球中朊病毒感染的特征

• 发表时间: 2011
• 作者: Sassa Y;et al.
• 通讯作者: et al.

Analysis of intracellular dynamics of inoculated PrP-res and newly generated PrPSc in Neuro2a cells

Neuro2a 细胞中接种的 PrP-res 和新生成的 PrPSc 的细胞内动力学分析

• 发表时间: 2012
• 作者: Yamasaki;T.
• 通讯作者: T.

Identification of chemoattractive factors involved in the migration of bone marrow-derived mesenchymal stem cells to brain lesions caused by prion

骨髓间充质干细胞向朊病毒引起的脑损伤迁移的趋化因子的鉴定

• DOI: 10.1128/jvi.05318-11
• 发表时间: 2011
• 期刊: J.Virol.
• 作者: Song;C.H.;et al
• 通讯作者: et al