Identification of factors that involved in migration of mesenchymal stem cells to lesions of neurodegenerative diseases
Identification of factors that involved in migration of mesenchymal stem cells to lesions of neurodegenerative diseases
批准号:
23658233
负责人:
HORIUCHI Motohiro
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
In vitro migration assay was carried out to investigate chemoattractive factors for MSCs in the brain lesions of prion-infected mice. In addition, expression of chemokine receptor on MSCs that had been transplanted in the brain of prion-infected mice was analyzed. The combined in vitro and in vivo analyses suggest that CCR3, CCR5, CXCR3 and CXCR4 and their corresponding ligands are involved in the migration of hMSCs to the brain lesions caused by prion propagation.
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Identification of chemoattractive factors involved in the migration of bone marrow-derived mesenchymal stem cells to brain lesions caused by prions
骨髓间充质干细胞向朊病毒引起的脑损伤迁移的趋化因子的鉴定
DOI:
--
发表时间:
2011
期刊:
J. Virol
影响因子:
--
作者:
[Song C.-H., Honmou, O., Furuoka, H. and Horiuchi, M]
通讯作者:
M
プリオンの感染と細胞内動態
朊病毒感染和细胞内动力学
DOI:
--
发表时间:
2013
期刊:
Dementia Japan
影响因子:
--
作者:
[山﨑 剛士, 堀内 基広]
通讯作者:
堀内 基広
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Sassa Y, et al.]
通讯作者:
et al.
Analysis of intracellular dynamics of inoculated PrP-res and newly generated PrPSc in Neuro2a cells
Neuro2a 细胞中接种的 PrP-res 和新生成的 PrPSc 的细胞内动力学分析
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Yamasaki, T.]
通讯作者:
T.
Identification of chemoattractive factors involved in the migration of bone marrow-derived mesenchymal stem cells to brain lesions caused by prion
骨髓间充质干细胞向朊病毒引起的脑损伤迁移的趋化因子的鉴定
DOI:
10.1128/jvi.05318-11
发表时间:
2011
期刊:
J.Virol.
影响因子:
--
作者:
[Song, C.H., et al]
通讯作者:
et al
共 19 条
Role of functional change of microglia in neuropathogenesis of prion diseases
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批准号:23248050
-
项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$30.28万
-
财政年份:2011
-
负责人:HORIUCHI Motohiro
-
依托单位:
Elucidation of the mechanism on the formation of early pathological lesion of prion diseases
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批准号:18208026
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$24.38万
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财政年份:2006
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负责人:HORIUCHI Motohiro
-
依托单位:
Molecluar mechanism of propagation of abnormal prion protein in the cells
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批准号:15208029
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$22.71万
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财政年份:2003
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负责人:HORIUCHI Motohiro
-
依托单位:
Studies on the entry ports for the scrapie agent (prion)
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批准号:12660268
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.7万
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财政年份:2000
-
负责人:HORIUCHI Motohiro
-
依托单位:
Etiological and molecular genetic surveillance of scrapie in Mongolia
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批准号:12575030
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.23万
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财政年份:2000
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负责人:HORIUCHI Motohiro
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依托单位:
海外基金