Elucidation of the mechanism on the formation of early pathological lesion of prion diseases

为了筛选在病毒感染早期表达上调的宿主基因，采用DNA微阵列技术分析了这些基因在病毒感染早期表达上调的情况，并分析了这些基因与病毒病病理生物学的关系。结果表明，CD14分子作为内毒素受体影响疾病的进展，而Cxcl10具有神经保护作用的趋化因子则起到拮抗疾病进展的作用。此外，小胶质细胞的激活被认为对疾病的进展具有保护作用。

To identify host genes whose expression is up-regulated in the early stage of prion-infection, DNA microarray analysis was carried out and involvement of the genes in pathobiology of prion diseases was analyzed. The results showed that Cd14 molecule, known as receptor for LPS, influences the progression of the disease, whereas, Cxcl10, known as chemokine with neuroprotective effect, plays a role in antagonizing the disease progression. In addition, microglial activation was suggested to have a protective effect on the disease progression.