Cellular mechanisms of nociception and nociceptive modulation in lateral and medial thalamocortical circuits in mice (B10)

丘脑和皮层之间的相互连接在调节传入的伤害性活动的流动以及自上而下的疼痛处理调制中起着重要作用。B10将建立在感觉皮层第6层抑制腹后外侧丘脑的第一个资助期的发现基础上，现在通过小鼠体内电生理学来解决细胞机制。这将使我们能够深入了解通过皮质-丘脑-皮质回路的疼痛相关信号的层状信号传播，并能够利用它们来优化未来慢性疼痛治疗中的特定脑刺激范例。

Reciprocal connections between the thalamus and the cortex plan an important role in regulating the flow of incoming nociceptive activity as well as top-down modulation of pain processing. B10 will build on findings from the first funding period of suppression of the ventroposterolateral thalamus by layer 6 of the sensory cortex to now address cellular mechanisms via in vivo electrophysiology in mice. This will enable deep insights into laminar signal propagation of pain-related signals through cortico-thalamo-cortical circuits and enable harnessing them to optimize specific brain stimulation paradigms in the future therapy of chronic pain.