The ventilatory effect of the percutaneous electrical stimulation of phrenic nerve

本研究旨在阐明经皮电刺激和磁刺激膈神经的镇痛效果，并探讨其作为人工呼吸机临床应用的可能性，主要通过潮气量和跨膜压来评价其镇痛效果。产生最大潮气量的最佳电刺激频率和脉宽为50- 150 Hz和0.5- 1 ms。经皮磁刺激也能产生同样的无痛性效果，可以制作出体积很小的流量计，并具有与传统流量计相似的特性。长期经皮磁刺激对颈部膈神经以外的其他神经的生物学影响有待进一步研究。

The purpose of this study is to clarify the ventilatory effect of percutaneous electrical as well as magnetic stimulation of phrenic nerve and to investigate the possibility of clinical application as an artificial ventilator.The ventilatory effects were evaluated mainly by tidal volume and transdiaphragmatic pressure. The optimum values for electrically stimulating frequency and pulse width to produce the maximum tidal volume were 50-150Hz and 0.5-1m sec. respectively.The same ventilatory effects could also be painlessly generated by the percutaneous magnetic stimulation as well.The very small sized flowmeter could be fabricated and have the similar characteristics to conventional ones. The further research on the biological influences to the other nerves except phrenic nerve at neck in the case of longterm percutaneous magnetic stimulation should be necessary to study.