Development of Noninvasive Ultrasonic Measurement Device for Visco-elastic Properties of Vessel Wall

血管壁粘弹性无创超声测量装置的研制

• 批准号: 59870031
• 负责人: YASUDA Hisakazu
• 金额: $ 4.1万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research
• 财政年份: 1984
• 资助国家: 日本
• 起止时间: 1984 至 1985
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-59870031/
• 关键词: noninvasive measurement; ultrasonic measurement; visco-elastic properties; elastic properties; aortic sclerosis; 動脈硬化

To measure noninvasively the elastic properties of in vivo human arteries including deep aorta, which had not been able to be measured hitherto, a new echo tracking device linked to cross-sectional echography was deyeloped. The accuracy of the device for pulsatile diameter change( <delta> D) was <10^(-3)> mm and for diameter(D) was around 0.5mm respectively, and was sufficient to measure the visco-elastic properties of arterial wall. The pressure strain elastic modulus (Ep) of the abdominal aorta were noninvasively measured in 61 healthy subjects(20-89 years) with this ultrasonic device from <delta> D, D and blood pressure obtained by auscultatory method. The mean Ep value was 2.1 x <10^6> dyne/ <cm^2> . Ep was significantly increased with age(p<0.001), The regression equation relating Ep to age was Ep=(-0.72+0.058 x age)x <10^6> dyne/ <cm^2> (r=0.73). In the systemic measurement of elastic properties in arterial tree from aorta to brachial and popliteal artery in 4 healthy subjects, t … More he elevation of Ep value was found in the peripheral site of the artery. In the measurement of age-matched 42 healthy subjects and 32 patients with coronary artery disease(CAD)(40-60 years), Ep was 0.99 and 1.83 x <10^6> dyne/ <cm^2> respectively. A significant sclerotic change(p<0.001) was found also in the abdominal aorta in CAD patients compared with normal subjects. A significant correlation(p<0.01) between Ep value and the value of blood total cholesterol was found in the CAD patients. Accelerating factor like a coronary risk factor was suspected to influence also the progression of aortic sclerosis. Furthermore, with the device and the additional use of catherter tip micromanometer for blood pressure measurement, visco-elastic properties of aorta in vivo were obtained in 14 subjects from the area of the hysteresis loop in the pressure-radius relationship with computer system. Coefficient of viscosity( <eta> ) 2.34 x <10^4> dyne.s/ <cm^2> , viscous loss modulus( <eta> <omega> ) 1.83 x <10^6> dyne/ <cm^2> , and phase angle( <phi> ) 0.087 radian, Ep 2.02 x <10^6> dyne/ <cm^2> were obtained. Less

为了无创测量包括深主动脉在内的活体动脉的弹性特性，研制了一种新型的与横断面超声成像相结合的回声跟踪装置。该装置脉动直径变化（< δ > D）的精度分别小于10^(-3)> mm，直径(D)的精度在0.5mm左右，足以测量动脉壁的粘弹性。本文对61例20 ~ 89岁的健康人进行了无创腹主动脉压力应变弹性模量（Ep）的测量，测量值为< δ > D、D及听诊法测得的血压。平均Ep值为2.1 x <10^6>达因/ <cm^2>。Ep随年龄的增加而显著升高（p<0.001）， Ep与年龄的回归方程为Ep=（-0.72+0.058 ×年龄）x <10^6> dyne/ <cm^2> (r=0.73)。4例健康人全身测量主动脉至肱动脉及腘动脉的动脉树弹性特性，发现动脉外周部位Ep值升高较多。在年龄匹配的42名健康受试者和32名冠心病患者（40-60岁）中，Ep分别为0.99和1.83 x <10^6> dyne/ <cm^2>。与正常受试者相比，冠心病患者的腹主动脉也有明显的硬化改变（p<0.001）。冠心病患者Ep值与血总胆固醇值有显著相关（p<0.01）。像冠状动脉危险因素这样的加速因素被怀疑也会影响主动脉硬化的进展。此外，利用该装置和附加的导管尖端微压计进行血压测量，通过计算机系统从压力-半径关系中的滞回线面积获得了14名受试者体内主动脉的粘弹性特性。粘度系数（<eta>） 2.34 x <10^4>达因。得到粘滞损失模量（<eta> <omega>） 1.83 x <10^6> dyne/ <cm^2>，相位角（<phi>） 0.087弧度，Ep 2.02 x <10^6> dyne/ <cm^2>。少

项目成果

北海道医学雑誌. 60-5. (1985)

北海道医学杂志。60-5。

Atherosclerosis. submitted. (1986)

动脉粥样硬化。

The Hokkaido Journal of Medical Science. 61:5. (1985)

北海道医学杂志。

Cardiovascular Research. 20-3. (1986)

心血管研究。

Atherosclerosis. (1986)

动脉粥样硬化。