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Development of stone-disintegrater for upper urinary tract calculi using focused underwater shock waves

开发利用水下聚焦冲击波治疗上尿路结石的碎石机

基本信息

批准号：
59870052
负责人：
KUWAHARA Masa-aki
金额：
$ 4.93万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research
财政年份：
1984
资助国家：
日本
起止时间：
1984 至 1985
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-59870052/
关键词：
Underwater shock wave focusing Urinary calculi Extracorporeal stone disintegrater Clinical usage 臨床応用

项目摘要

We studied on the focusing of underwater shock wave, generated by high voltage sparks, or microexplosions, for the purpose of extra corporeal renal stone disintegration, and obtained following results.1. The shock wave generated by explosive material, lead azide pellet, could be focused in the same manner as the shock wave generated by high voltage sparks. The focused shock wave disintegrated extracted human calculi, or model calculi without difficulty.2. Either extracted human calculus or model calculus was implanted in a living dog kidney, and the calculus was targeted at the focus area of an ellipsoidal reflector. The shock waves were generated by microexplosions of lead azide pellet of 10mg, inside the reflector. The calculus was disintegrated in the kidney without damaging abdominal organs, including the kidney, which was confirmed by microscopic examination, in addition to the inspection.3. Following to the animal experimets, the clinical applications were performed using a proto-type of disintegrator. From April, 1985 to February, 1986, we applied the method, extracorporeal microexplosive lithotripsy (EML), to 100 stone-patients. The results were satisfactory, the success rate of stone disintegration was more than 95 %.Improvements of the system are necessary to its wide and easy use. In this regard, further investigations are also required.

本研究对高压火花或微爆炸产生的水下冲击波聚焦用于体外碎石进行了研究，取得了以下结果。爆炸材料叠氮化铅丸产生的冲击波可以像高压火花产生的冲击波一样被聚焦。结论：1.聚焦冲击波崩解提取的人体结石，或模型结石无困难。无论是提取的人体结石还是模型结石，都被植入了活体狗的肾脏，并瞄准了椭球反射器的焦点区域。冲击波是由10 mg的叠氮化铅球在反射器内微爆炸产生的。结石在肾脏内解体，没有损伤腹部器官，包括肾脏，这是通过显微镜检查，除了检查外，证实。在动物实验之后，使用原型式粉碎器进行临床应用。自1985年4月至1986年2月，我们应用体外微爆炸碎石术(EML)治疗结石100例。结果令人满意，碎石成功率达95%以上，需要对系统进行改进，使其更广泛、更方便地使用。在这方面，还需要进一步调查。