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Development of Non-Invasive Deep Heating Equipment for Local Hyperthermia.

用于局部热疗的非侵入性深层加热设备的开发。

基本信息

批准号：
61870044
负责人：
KATO Hirokazu
金额：
$ 16万
依托单位：
Shimane Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1988
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-61870044/
关键词：
Hyperthermia Heating equipment 加温装置誘導加温深部加温

项目摘要

To deliver electromagnetic energy to a deep portion of the body. RF at a lower frequency is needed. Appricators driven at lower frequency include 1) capacitive type applocator, 2)inductive applicator, 3) ridge waveguide type applicator filled with water, and 4) horn type applicator. They have their own problems so that we designed an inductive aperture-type applicator, IATA, for the purpose of resolving their problems. The applicator consists of 6 sheets of copper strips 0.3 mm in thickness. The applicator is a 3/4-turn square coil made of the strips which are bent like the shape of the Russian letter. "PI". One of the surfaces serves as an aperture. We developed heating equipment with IATA, "Inductron", for clinical use. The Inductron is driven at 13.56 MHz with a maximum power of 10 KW. The bed, the gantry, and the applicator of the Inductron are movable in various directions, so that the aperture can face any portion of the patients' body. Eighteen patients were treated with hyperthermia twice a week just after radiation therapy which was applied 5 times a week, and one patients was treated with hyperthermia alone. Four of 19 patients had metastatic skin lesions located within 0.5 cm of the skin surface. Fifteen of 19 patients had tumors located 1 to 5 cm in depth from the skin. Heat was applied to the body without contact to the applicator. The highest temperature in the tumor was 48.3゜C and the tumors were heated above 42゜C for 10 to 50 minutes. The overall respose rate is 13/19. But the response rate without the patient who had hyperthermia treatment without radiation therapy and had hyperthermia treatment less than 4 times was 12/14. We plan to treat deep seated tumors hereafter.

把电磁能量传送到身体深处。需要较低频率的RF。在较低频率下驱动的施用器包括1）电容式施用器，2）电感式施用器，3）填充有水的脊波导式施用器，以及4）喇叭式施用器。他们有自己的问题，所以我们设计了一个感应孔径式施源器，IATA，为解决他们的问题。涂敷器由6片0.3 mm厚的铜带组成。施源器是一个3/4匝的方形线圈，由弯曲成俄文字母形状的条带制成。“圆周率”。其中一个表面用作孔。我们与IATA合作开发了用于临床的加热设备“Inductron”。Inductron的驱动频率为13.56 MHz，最大功率为10 KW。床、机架和感应器的施加器可在各个方向上移动，因此孔径可以面向患者身体的任何部分。18例患者在每周5次放疗后立即进行每周2次热疗，1例患者仅进行热疗。19例患者中有4例转移性皮肤病变位于皮肤表面0.5 cm内。19例患者中有15例肿瘤位于距离皮肤1至5 cm的深度。在不接触施源器的情况下对身体进行加热。肿瘤中的最高温度为48.3摄氏度，并将肿瘤加热至42摄氏度以上10至50分钟。总回收率为13/19。但不包括接受过热疗而未接受过放疗及热疗次数少于4次的患者，有效率为12/14。我们计划以后治疗深部肿瘤。