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Development of a phantom compatible for MRI and hyperthermia equivalent to relaxation times and dielectric properties of the human tissues

开发与 MRI 和热疗兼容的体模，相当于人体组织的弛豫时间和介电特性

基本信息

批准号：
13670942
负责人：
KATO Hirokazu
金额：
$ 2.3万
依托单位：
OKAYAMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670942/
关键词：
MRI Hyperthermia Phantom

项目摘要

We developed a phantom compatible for MRI and hyperthermia equivalent to relaxation times and dielectric properties of the human tissues. The phantom consists of 0 -140 μmol/kg GdCl_3, 0 -1.6 % agarose, 0 -0.7 % NaCl, 3 % carrageenan and 0.03 % NaN_3, with water as the remainder. The phantom has a T1 value of 202 to 1,904 ms and a T2 value of 38 to 423 ms at 1.5 T, and has conductivity of 0.27 to 1.26 S/m and relative permittivity of 78.1 to 98.9 for the frequency range of 5 -130 MHz.The phantom developed has the following characteristics;1) The phantom contains carrageenan as a solidifying agent, and allows its use in producing a torso phantom without the use of physical reinforcements.2) T1 and T2 relaxation times of the phantom are independently changeable by varying the concentrations of GdCl_3 as Tv modifier and agarose as T2 modifier. Thus, the range of the T1 and T2 relaxation times of the phantom can be adjusted to correspond to those of all human tissues.3) Conductivity of the phantom is changeable by changing the concentration of NaCl.4) As NaN_3 is admixed as a preservative, the phantom remains chemically and physically stable over extended periods.5) The appropriate concentrations of GdCl_3, agarose and NaCl can be determined from the empirical formulae which are deduced from the experimental data, when making a specified phantom that has the required relaxation times and conductivity.Thus, the phantom developed is useful for basic studies of MRI and hyperthermia, QA of MRI equipment, and training MRI operators and radiologists.

我们开发了一种与MRI和热疗兼容的体模，相当于人体组织的弛豫时间和介电特性。体模由0 - 140 μmol/kg GdCl_3、0 - 1.6%琼脂糖、0 - 0.7%NaCl、3%卡拉胶和0.03%NaN_3组成，余量为水。该体模在1.5T时的T1值为202 ~ 1904 ms，T2值为38 ~ 423 ms，在5 ~ 130 MHz频率范围内的电导率为0.27 ~ 1.26S/m，相对介电常数为78.1 ~ 98.9。1）该体模含有角叉菜胶作为固化剂，可以在不使用物理固化剂的情况下用于制作躯干体模。2）通过改变GdCl_3作为Tv调节剂和琼脂糖作为T2调节剂的浓度，可以独立地改变体模的T1和T2弛豫时间。3）通过改变NaCl的浓度可以改变体模的电导率; 4）由于加入NaN_3作为防腐剂，体模在较长时间内保持化学和物理稳定; 5）适当的GdCl_3浓度，琼脂糖和NaCl的浓度可由实验数据推导出的经验公式确定，从而可制作出满足弛豫时间和电导率要求的体模，为MRI和热疗的基础研究、MRI设备的质量保证、MRI操作人员和放射科医师的培训提供了有用的工具。