Molecular triggers for neuropathy and neural invasion in pancreatic ductal adenocarcinoma (P07)

胰腺导管腺癌神经病变和神经侵袭的分子触发因素 (P07)

• 批准号: 403628975
• 金额: --
• 依托单位: Klinik und Poliklinik für Chirurgie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/403628975?language=en
• 关键词: Molecular; triggers; neuropathy; neural; invasion

Neural invasion (NI) is frequent and clinically overwhelming problem in human pancreatic cancer, which associates with markedly worsened overall survival and severe pain in patients. NI has not yet been sufficiently modelled in experimental research. We developed and characterised novel mouse models and organoid culture setups of NI in PDAC. Using these innovative tools, we will explore the molecules that trigger NI in mouse PDAC and will delve deeper into the molecular mechanisms that give rise to NI. Furthermore, we will generate faster and more human-like, neuro-invasive models with the ultimate goal of targeting NI in human PDAC.

神经侵袭（NI）是人类胰腺癌中常见且临床上压倒性的问题，它与患者的总体生存率显着恶化和严重疼痛有关。 NI 尚未在实验研究中得到充分的建模。我们开发并表征了 PDAC 中 NI 的新型小鼠模型和类器官培养装置。利用这些创新工具，我们将探索在小鼠 PDAC 中触发 NI 的分子，并将更深入地研究引起 NI 的分子机制。此外，我们将生成更快、更接近人类的神经侵入模型，最终目标是针对人类 PDAC 中的 NI。