Molecular triggers for neuropathy and neural invasion in pancreatic ductal adenocarcinoma (P07)

神经侵犯（NI）是人类胰腺癌中常见的、临床上压倒性的问题，它与患者的总生存期明显恶化和严重疼痛有关。NI还没有在实验研究中得到充分的模拟。我们在PDAC中开发并鉴定了新的小鼠模型和NI类器官培养装置。利用这些创新的工具，我们将探索在小鼠PDAC中触发NI的分子，并将深入研究产生NI的分子机制。此外，我们将产生更快、更像人类的神经侵入模型，最终目标是在人类PDAC中靶向NI。

Neural invasion (NI) is frequent and clinically overwhelming problem in human pancreatic cancer, which associates with markedly worsened overall survival and severe pain in patients. NI has not yet been sufficiently modelled in experimental research. We developed and characterised novel mouse models and organoid culture setups of NI in PDAC. Using these innovative tools, we will explore the molecules that trigger NI in mouse PDAC and will delve deeper into the molecular mechanisms that give rise to NI. Furthermore, we will generate faster and more human-like, neuro-invasive models with the ultimate goal of targeting NI in human PDAC.